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CRISPR Services

CRISPR/Cas9 genome editing has become widely used due to its simplicity and versatility, and the CRISPR technology has been adapted for diverse applications aside from genome editing. As a leader in gene synthesis and genome editing, and through our partnership with Feng Zhang's laboratory at the Broad Institute of MIT and Harvard*, GenScript offers validated CRISPR products, services and resources to help you harness the power of CRISPR genome editing for your research.

What is CRISPR?

CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. CRISPR sequences were originally identified in the Escherichia coli (E. coli) genome, and were found to function as part of an RNA-based adaptive immune system to target and destroy genetic parasites at the DNA level. Read More »

Helpful CRISPR Resources

If you are new to CRISPR, GenScript has a variety of free resources to how you learn more about the technology, common issues or bottlenecks, and other recommendations for implementing CRISPR into your research.

CRISPR Handbook – Enabling Genome Editing and Transforming Life Science

CRISPR Handbook – Enabling Genome Editing and Transforming Life Science

A concise resource on the history of CRISPR, along with workflows and protocols to jump-start your gene editing research

CRISPR Handbook – Enabling Genome Editing and Transforming Life Science

CRISPR Webinars

Watch previously-aired webinars on-demand, with helpful tips on designing and using gRNA and Cas9 constructs, CRISPR libraries, designing KO mammalian cell lines, and more!

CRISPR Frequently Asked Questions

Have questions about CRISPR/Cas9? Learn more about the advantages of CRISPR and how to integrate it into your research.

  1. What are the advantages of CRISPR gene editing? Read More »
  2. How does CRISPR/Cas9 modify eukaryotic genomes? Read More »
  3. How are CRISPR reagents delivered to cells? Read More »
  4. How efficient and specific is CRISPR-mediated genome editing with gRNA constructs designed by GenScript? Read More »
  5. What expression vector should I use? Read More »
  6. How can I use CRISPR reagents for genome editing in mammalian cell lines? Read More »

CRISPR Products and Services at GenScript

To accelerate your research, GenScript offers validated CRISPR products, services and resources to help you harness the power of CRISPR genome editing.

New Synthetic crRNA service

  • DNA-free, rapid gene editing in any cell type
  • Pre-synthesized, validated crRNA:tracrRNA sequences

Learn More »
gRNA sequence databases

Validated, in-stock gRNA sequences targeting human and mouse genes for efficient, specific targeting of WT SpCas9 and transcription activation complexes

  gRNA design tool

Developed by Feng Zheng at the Broad Institute, design gRNAs on-demand for any DNA sequence in multiple species

CRISPR gRNA constructs

All-in-one or dual SpCas9, Nickase & SaCas9 constructs for single guide RNA expression; SAM constructs for transcription activation

  CRISPR gRNA libraries

In-stock GeCKO libraries for genome-wide knock-out; SAM libraries for genome-scale transcription activation

CRISPR-edited mammalian cell lines

Fully-validated KO cell lines and cell pools using
CRISPR technology

  Microbial gene editing

Efficient genome editing in yeast and bacteria using
CRISPR technology

Purified Cas9 proteins

Get high-efficiency gene editing with purified Cas9 proteins and other products

  Genomic DNA sequencing

Affordable sequencing of single and pooled clones

*Legal Statement of GenCRISPR Services and Products (updated on July 28, 2015):

  1. GenCRISPR™ services and products are covered under US 8,697,359, US 8,771,945, US 8,795,965, US 8,865,406, US 8,871,445, US 8,889,356, US 8,889,418, US 8,895,308, US 8,906,616 and foreign equivalents and licensed from Broad Institute, Inc. Cambridge, Massachusetts.
  2. The products and the reagents generated from these services shall be used as tools for research purposes, and shall exclude (a) any human or clinical use, including, without limitation, any administration into humans or any diagnostic or prognostic use, (b) any human germline modification, including modifying the DNA of human embryos or human reproductive cells, (c) any in vivo veterinary or livestock use, or (d) the manufacture, distribution, importation, exportation, transportation, sale, offer for sale, marketing, promotion or other exploitation or use of, or as, a testing service, therapeutic or diagnostic for humans or animals.
  3. The purchase of the GenCRISPR Services and Products coveys to the purchaser the limited, non-transferable right to use the products purchased and the reagents generated from GenCRISPR services and any related material solely for Research Purposes only, not for any Commercial Purposes.

How to Order CRISPR services from GenScript

Have questions? GenScript's Ph.D.-level service representatives are available 24 hours a day, Monday through Friday, to assist you.