Custom Modified DNA Oligos |
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GenScript, as the largest gene synthesis provider in the USA, provides affordable custom modified DNA oligos with comprehensive modifications and labeling to meet research needs in biology, diagnostics, and drug discovery. We specialize in oligonucleotides labeled by fluorescent or non-fluorescent dyes, quencher pairs, or electrochemicals for qualitative and quantitative detection. These oligonucleotides are rapidly coming into use in genetic testing and personalized medicine. In principle, we do not provide synthesis service for single DNA oligonucleotide without any modification or labeling. However, we provide unmodified DNA oligo synthesis service for large-scale order (at least 96 DNA-Oligos).
DNA oligos produced by GenScript's state-of-the-art oligo-synthesizer have substantial purity with low truncated sequences. Each oligo is meticulously monitored during synthesis and controlled according to GenScript's stringent quality assurance and quality control standards. The final product is identified by mass spectrum and purity is analyzed by high throughput capillary gel electrophoresis.
Competitive Advantages:
- Comprehensive Modifications and Labeling: from general modifications to fluorescent/non-fluorescent labeling, and even dual and multiple labeling
- Flexible Synthesis Scales: 50 nmol, 100 nmol, 200 nmol, 1 µmol, 5 µmol, and 10 µmol. Bulk orders are available upon request
- Experienced Team: scientists and staff with over 20 years of experience in oligo synthesis and modifications
- High Quality: ISO9001 certificated, comprehensive quality control report (HPLC, MS, CGE)
- Cost Effective: competitive prices, especially at 50 nmol scale
- Services
- Modifications/Labeling
- Dual/Multiple Labeling
- Delivery Specifications
DNA Oligo Synthesis:
GenScript provides modified DNA oligos with flexible synthesis scales for your individual research needs. The mini package at 50 nmol scale is especially designed for avoiding waste in a tight budget. Bulk orders are also available upon request.
| Price per Base for DNA Oligo |
Length |
50 nmol |
100 nmol |
200 nmol |
1 µmol |
5 µmol |
10 µmol |
15 - 60 mer |
$0.39 |
$0.45 |
$0.79 |
$1.75 |
$8.19 |
$14.99 |
* Please inquire for other lengths and bulk orders.
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Modification/Labeling:
GenScript provides comprehensive modifications for your individual research need. The modifications range from
- General modifications such as modified bases, phosphorylation, thiolation, linkages, etc.
- Labeling such as fluorescent/non-fluorescent dye labeling, dual-labeled probes for real-time qPCR, and multiple labeling
- Backbone modifications such as DNA containing thiophosphodiester linkages.
Purification:
Oligonucleotides purification can be accomplished by various methods. The options listed below are used frequently. Please contact a sales representative for a special request such as Dual HPLC, Dual PAGE & HPLC, or other combinations.
| Price for DNA Oligo Purification |
Purification |
50 nmol |
100 nmol |
200 nmol |
1 µmol |
5 µmol |
10 µmol |
Desalt |
free |
free |
free |
free |
free |
free |
RPC |
$20.00 |
$22.00 |
$24.00 |
$36.00 |
$62.00 |
$110.00 |
PAGE |
$35.00 |
$40.00 |
$60.00 |
$105.00 |
$525.00 |
$915.00 |
HPLC |
$38.00 |
$38.00 |
$58.00 |
$94.00 |
$215.00 |
$315.00 |
| Guaranteed Purification Yield for Unmodified DNA Oligo |
Purification |
50 nmol |
100 nmol |
200 nmol |
1 µmol |
5 µmol |
10 µmol |
Desalt |
3 OD |
6 OD |
10 OD |
45 OD |
200 OD |
400 OD |
RPC |
2 OD |
5 OD |
8 OD |
45 OD |
200 OD |
400 OD |
PAGE |
1 OD |
2 OD |
3 OD |
10 OD |
45 OD |
100 OD |
HPLC |
1 OD |
2 OD |
4 OD |
20 OD |
100 OD |
200 OD |
*Yield guarantee only for unmodified DNA oligo of 15-60 bases in length.
*Modifications can affect yield. |
Additional Service:
Extra $0.20/tube for aliquoting into over 5 tubes.
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Modification/Labeling
| Classification |
Modification |
50 nmol |
100 nmol |
200 nmol |
1 µmol |
5 µmol |
10 µmol |
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dI |
$6.00 |
$7.00 |
$9.00 |
$13.50 |
$27.00 |
$54.00 |
dU |
$6.00 |
$7.00 |
$9.00 |
$13.50 |
$27.00 |
$54.00 |
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SPO3 |
$2.60 |
$3.25 |
$3.25 |
$4.50 |
$18.00 |
$27.00 |
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5' PO4 |
$15.00 |
$18.00 |
$23.00 |
$39.00 |
$78.00 |
$155.00 |
3' PO4 |
$17.60 |
$22.00 |
$28.00 |
$44.00 |
$110.00 |
$220.00 |
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3' or 5' NH2 C3 |
$18.00 |
$21.00 |
$26.00 |
$44.00 |
$90.00 |
$180.00 |
5' NH2 C6 |
$18.00 |
$21.00 |
$26.00 |
$44.00 |
$90.00 |
$180.00 |
3' NH2 C7 |
$18.00 |
$21.00 |
$26.00 |
$44.00 |
$90.00 |
$180.00 |
5' NH2 C12 |
$45.00 |
$48.00 |
$62.00 |
$94.00 |
$190.00 |
$380.00 |
NH2 C6 dT |
$95.00 |
$110.00 |
$135.00 |
$200.00 |
$400.00 |
$800.00 |
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3' C3 S-S |
$68.00 |
$85.00 |
$85.00 |
$130.00 |
$335.00 |
$670.00 |
5' C6 S-S |
$88.00 |
$110.00 |
$110.00 |
$175.00 |
$350.00 |
$700.00 |
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Spacer C3 |
$30.00 |
$35.00 |
$45.00 |
$67.50 |
$135.00 |
$270.00 |
Spacer C6 |
$56.00 |
$70.00 |
$90.00 |
$100.00 |
$200.00 |
$400.00 |
Spacer 9 |
$30.00 |
$35.00 |
$45.00 |
$67.50 |
$135.00 |
$270.00 |
Spacer 18 |
$45.00 |
$50.00 |
$55.00 |
$80.00 |
$160.00 |
$320.00 |
dSpacer |
$60.00 |
$75.00 |
$90.00 |
$135.00 |
$270.00 |
$540.00 |
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5' Biotin |
$30.00 |
$36.00 |
$45.00 |
$90.00 |
$185.00 |
$370.00 |
3' Biotin |
$45.00 |
$52.50 |
$66.00 |
$102.00 |
$260.00 |
$520.00 |
5' Biotin TEG |
$49.60 |
$62.00 |
$78.00 |
$110.00 |
$270.00 |
$540.00 |
3' Biotin TEG |
$47.00 |
$55.00 |
$70.00 |
$105.00 |
$237.50 |
$475.00 |
5' Dual Biotin |
$140.00 |
$175.00 |
$175.00 |
$270.00 |
$410.00 |
$820.00 |
5' or Internal Biotin dT |
$124.00 |
$155.00 |
$155.00 |
$245.00 |
$620.00 |
$1,240.00 |
5' PC Biotin |
$100.00 |
$125.00 |
$125.00 |
$240.00 |
$600.00 |
$1,200.00 |
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3' or 5' Digoxin |
$85.00 |
$100.00 |
$105.00 |
$160.00 |
$600.00 |
$1,200.00 |
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5' Cy3 |
$62.00 |
$70.00 |
$90.00 |
$135.00 |
$405.00 |
$810.00 |
3' Cy3 |
$80.00 |
$92.00 |
$110.00 |
$165.00 |
$500.00 |
$1,000.00 |
Internal Cy3 |
$135.00 |
$155.00 |
$190.00 |
$280.00 |
$875.00 |
$1,750.00 |
5' Cy5 |
$62.00 |
$70.00 |
$90.00 |
$135.00 |
$405.00 |
$810.00 |
3' Cy5 |
$80.00 |
$92.00 |
$110.00 |
$165.00 |
$500.00 |
$1,000.00 |
Internal Cy5 |
$135.00 |
$155.00 |
$190.00 |
$280.00 |
$875.00 |
$1,750.00 |
5' FAM |
$48.00 |
$55.00 |
$70.00 |
$135.00 |
$270.00 |
$540.00 |
3' FAM |
$48.00 |
$55.00 |
$70.00 |
$135.00 |
$335.00 |
$670.00 |
5' HEX |
$48.00 |
$55.00 |
$70.00 |
$135.00 |
$270.00 |
$540.00 |
5' TET |
$48.00 |
$55.00 |
$70.00 |
$135.00 |
$270.00 |
$540.00 |
5' or 3' 6-JOE |
$136.00 |
$170.00 |
$170.00 |
$260.00 |
$420.00 |
$840.00 |
5' Rox |
$90.00 |
$115.00 |
$130.00 |
$185.00 |
$370.00 |
$740.00 |
5' or 3' TAMRA |
$80.00 |
$90.00 |
$112.50 |
$175.00 |
$350.00 |
$700.00 |
Internal TAMRA |
$155.00 |
$180.00 |
$205.00 |
$360.00 |
$650.00 |
$1,300.00 |
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3' DABCYL |
$62.00 |
$70.00 |
$90.00 |
$135.00 |
$345.00 |
$690.00 |
3' BHQ 1 |
$62.00 |
$70.00 |
$90.00 |
$135.00 |
$540.00 |
$1,080.00 |
3' BHQ 2 |
$62.00 |
$70.00 |
$90.00 |
$135.00 |
$540.00 |
$1,080.00 |
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Ferrocene |
$80.00 |
$100.00 |
$125.00 |
$190.00 |
$760.00 |
$1,520.00 |
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Please quote |
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Dual-Labeld Fluorogenic Probes
| 3' Modification |
5' Modification |
50 nmol |
100 nmol |
200 nmol |
1 µmol |
5 µmol |
10 µmol |
3' TAMRA |
5' FAM |
$128.00 |
$145.00 |
$182.50 |
$310.00 |
$620.00 |
$1,240.00 |
5' TET |
$128.00 |
$145.00 |
$182.50 |
$310.00 |
$620.00 |
$1,240.00 |
5' HEX |
$128.00 |
$145.00 |
$182.50 |
$310.00 |
$620.00 |
$1,240.00 |
5' JOE |
$216.00 |
$260.00 |
$282.50 |
$435.00 |
$770.00 |
$1,540.00 |
3' DABCYL |
5' FAM |
$110.00 |
$125.00 |
$160.00 |
$270.00 |
$615.00 |
$1,230.00 |
5' HEX |
$110.00 |
$125.00 |
$160.00 |
$270.00 |
$615.00 |
$1,230.00 |
5' TET |
$110.00 |
$125.00 |
$160.00 |
$270.00 |
$615.00 |
$1,230.00 |
5' JOE |
$198.00 |
$240.00 |
$260.00 |
$395.00 |
$765.00 |
$1,530.00 |
5' TAMRA |
$142.00 |
$160.00 |
$202.50 |
$310.00 |
$695.00 |
$1,390.00 |
5' Cy5 |
$124.00 |
$140.00 |
$180.00 |
$270.00 |
$750.00 |
$1,500.00 |
3' BHQ1 |
5' FAM |
$110.00 |
$125.00 |
$160.00 |
$270.00 |
$810.00 |
$1,620.00 |
5' HEX |
$110.00 |
$125.00 |
$160.00 |
$270.00 |
$810.00 |
$1,620.00 |
5' JOE |
$198.00 |
$240.00 |
$260.00 |
$395.00 |
$960.00 |
$1,920.00 |
Others |
Please quote |
Multiple Labeling
GenScript can also incorporate more than one label within a single oligo. Please complete a quote for multiple labeling.
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Delivery Specifications:
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Turnaround:
5-7 business days
Deliverables:
Your desired oligonucleotides in tubes
Certificate of analysis (COA)
MS report
HPLC report
CGE report
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Quotations and Ordering
 For quotations, please use our secured Online Quotation/Ordering system. However, you may also contact us by email, phone (1-732-885-9188) or fax (1-732-210-0262).
Orders can be placed directly through our secured Online Quotation/Ordering system with a formal PO (Purchase Order) or credit card.
For batch orders, please download and complete our Quick Quotation Request and send it to us via email or fax.
Our customer service representatives are available 24 hours Monday through Friday. You may contact us anytime for assistance.
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