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Custom DNA Oligos

Custom Modified DNA & RNA Oligos

  oligo services quotation

GenScript, as the largest gene synthesis provider in the USA, provides affordable custom modified DNA oligos  and RNA oligos.

Genscript offers comprehensive modifications and labeling to meet research needs in biology, diagnostics, and drug discovery. We specialize in oligonucleotides labeled by fluorescent or non-fluorescent dyes, quencher pairs, or electrochemicals for qualitative and quantitative detection. These oligonucleotides are rapidly coming into use in genetic testing and personalized medicine. We also provide unmodified DNA oligo synthesis for large-scale orders only (at least 96 DNA Oligos).

 DNA oligos produced by GenScript's state-of-the-art oligo-synthesizer have substantial purity with low truncated sequences. Each oligo is meticulously monitored during synthesis and controlled according to GenScript's stringent quality assurance and quality control standards. The final product is identified by mass spectrum and purity is analyzed by high throughput capillary gel electrophoresis.

Competitive Advantages:

  • Comprehensive Modifications and Labeling: from general modifications to fluorescent/non-fluorescent labeling, and even dual and multiple labeling
  • Flexible Synthesis Scales: 50 nmol, 100 nmol, 200 nmol, 1 µmol, 5 µmol, and 10 µmol. Bulk orders are available upon request
  • Experienced Team: scientists and staff with over 20 years of experience in oligo synthesis and modifications
  • High Quality: ISO9001 certificated, comprehensive quality control report (HPLC, MS, CGE)
  • Cost Effective: competitive prices, especially at 50 nmol scale
  • Services
  • Modifications/Labeling
  • Dual/Multiple Labeling
  • Delivery Specifications

DNA Oligo Synthesis:

GenScript provides modified DNA oligos with flexible synthesis scales for your individual research needs. The mini package at 50 nmol scale is especially designed for avoiding waste in a tight budget. Bulk orders are also available upon request.

Price per Base for DNA Oligo
Length
50 nmol
100 nmol
200 nmol
1 µmol
5 µmol
10 µmol
15 - 60 mer
$0.39
$0.45
$0.79
$1.75
$8.19
$14.99
* Please inquire for other lengths and bulk orders.

Modification/Labeling:

GenScript provides comprehensive modifications for your individual research need. The modifications range from

  • General modifications such as modified bases, phosphorylation, thiolation, linkages, etc.
  • Labeling such as fluorescent/non-fluorescent dye labeling, dual-labeled probes for real-time qPCR, and multiple labeling
  • Backbone modifications such as DNA containing thiophosphodiester linkages.

Purification:

Oligonucleotides purification can be accomplished by various methods. The options listed below are used frequently. Please contact a sales representative for a special request such as Dual HPLC, Dual PAGE & HPLC, or other combinations.

Price for DNA Oligo Purification
Purification
50 nmol
100 nmol
200 nmol
1 µmol
5 µmol
10 µmol
Desalt
free
free
free
free
free
free
RPC
$20.00
$22.00
$24.00
$36.00
$62.00
$110.00
PAGE
$35.00
$40.00
$60.00
$105.00
$525.00
$915.00
HPLC
$38.00
$38.00
$58.00
$94.00
$215.00
$315.00

Guaranteed Purification Yield for Unmodified DNA Oligo
Purification
50 nmol
100 nmol
200 nmol
1 µmol
5 µmol
10 µmol
Desalt
3 OD
6 OD
10 OD
45 OD
200 OD
400 OD
RPC
2 OD
5 OD
8 OD
45 OD
200 OD
400 OD
PAGE
1 OD
2 OD
3 OD
10 OD
45 OD
100 OD
HPLC
1 OD
2 OD
4 OD
20 OD
100 OD
200 OD
*Yield guarantee only for unmodified DNA oligo of 15-60 bases in length.
*Modifications can affect yield.

Additional Service:

Extra $0.20/tube for aliquoting into over 5 tubes.

Modification/Labeling

Modified Bases Phosphorothioates Phosphorylation Spacers
Amino Linkers Disulfide Linkers Biotin Digoxin
Fluorophores Electrochemical Labeling Quenchers

Classification Modification 50 nmol 100 nmol 200 nmol 1 µmol 5 µmol 10 µmol
Modified Bases
($/modified base)
dI
$6.00
$7.00
$9.00
$13.50
$27.00
$54.00
dU
$6.00
$7.00
$9.00
$13.50
$27.00
$54.00
SPO3
$2.60
$3.25
$3.25
$4.50
$18.00
$27.00
5' PO4
$15.00
$18.00
$23.00
$39.00
$78.00
$155.00
3' PO4
$17.60
$22.00
$28.00
$44.00
$110.00
$220.00
3' or 5' NH2 C3
$18.00
$21.00
$26.00
$44.00
$90.00
$180.00
5' NH2 C6
$18.00
$21.00
$26.00
$44.00
$90.00
$180.00
3' NH2 C7
$18.00
$21.00
$26.00
$44.00
$90.00
$180.00
5' NH2 C12
$45.00
$48.00
$62.00
$94.00
$190.00
$380.00
NH2 C6 dT
$95.00
$110.00
$135.00
$200.00
$400.00
$800.00
3' C3 S-S
$68.00
$85.00
$85.00
$130.00
$335.00
$670.00
5' C6 S-S
$88.00
$110.00
$110.00
$175.00
$350.00
$700.00
Spacer C3
$30.00
$35.00
$45.00
$67.50
$135.00
$270.00
Spacer C6
$56.00
$70.00
$90.00
$100.00
$200.00
$400.00
Spacer 9
$30.00
$35.00
$45.00
$67.50
$135.00
$270.00
Spacer 18
$45.00
$50.00
$55.00
$80.00
$160.00
$320.00
dSpacer
$60.00
$75.00
$90.00
$135.00
$270.00
$540.00
5' Biotin
$30.00
$36.00
$45.00
$90.00
$185.00
$370.00
3' Biotin
$45.00
$52.50
$66.00
$102.00
$260.00
$520.00
5' Biotin TEG
$49.60
$62.00
$78.00
$110.00
$270.00
$540.00
3' Biotin TEG
$47.00
$55.00
$70.00
$105.00
$237.50
$475.00
5' Dual Biotin
$140.00
$175.00
$175.00
$270.00
$410.00
$820.00
Internal Biotin dT
$124.00
$155.00
$155.00
$245.00
$620.00
$1,240.00
5' PC Biotin
$100.00
$125.00
$125.00
$240.00
$600.00
$1,200.00
3' or 5' Digoxin
$85.00
$100.00
$105.00
$160.00
$600.00
$1,200.00
5' Cy3
$62.00
$70.00
$90.00
$135.00
$405.00
$810.00
3' Cy3
$80.00
$92.00
$110.00
$165.00
$500.00
$1,000.00
Internal Cy3
$135.00
$155.00
$190.00
$280.00
$875.00
$1,750.00
5' Cy5
$62.00
$70.00
$90.00
$135.00
$405.00
$810.00
3' Cy5
$80.00
$92.00
$110.00
$165.00
$500.00
$1,000.00
Internal Cy5
$135.00
$155.00
$190.00
$280.00
$875.00
$1,750.00
5' FAM
$48.00
$55.00
$70.00
$135.00
$270.00
$540.00
3' FAM
$48.00
$55.00
$70.00
$135.00
$335.00
$670.00
5' HEX
$48.00
$55.00
$70.00
$135.00
$270.00
$540.00
5' TET
$48.00
$55.00
$70.00
$135.00
$270.00
$540.00
5' or 3' 6-JOE
$136.00
$170.00
$170.00
$260.00
$420.00
$840.00
5' Rox
$90.00
$115.00
$130.00
$185.00
$370.00
$740.00
5' or 3' TAMRA
$80.00
$90.00
$112.50
$175.00
$350.00
$700.00
Internal TAMRA
$155.00
$180.00
$205.00
$360.00
$650.00
$1,300.00
3' DABCYL
$62.00
$70.00
$90.00
$135.00
$345.00
$690.00
3' BHQ 1
$62.00
$70.00
$90.00
$135.00
$540.00
$1,080.00
3' BHQ 2
$62.00
$70.00
$90.00
$135.00
$540.00
$1,080.00
Ferrocene
$80.00
$100.00
$125.00
$190.00
$760.00
$1,520.00
Please quote

Dual-Labeld Fluorogenic Probes

3' Modification 5' Modification 50 nmol 100 nmol 200 nmol 1 µmol 5 µmol 10 µmol
3' TAMRA
5' FAM
$128.00
$145.00
$182.50
$310.00
$620.00
$1,240.00
5' TET
$128.00
$145.00
$182.50
$310.00
$620.00
$1,240.00
5' HEX
$128.00
$145.00
$182.50
$310.00
$620.00
$1,240.00
5' JOE
$216.00
$260.00
$282.50
$435.00
$770.00
$1,540.00
3' DABCYL
5' FAM
$110.00
$125.00
$160.00
$270.00
$615.00
$1,230.00
5' HEX
$110.00
$125.00
$160.00
$270.00
$615.00
$1,230.00
5' TET
$110.00
$125.00
$160.00
$270.00
$615.00
$1,230.00
5' JOE
$198.00
$240.00
$260.00
$395.00
$765.00
$1,530.00
5' TAMRA
$142.00
$160.00
$202.50
$310.00
$695.00
$1,390.00
5' Cy5
$124.00
$140.00
$180.00
$270.00
$750.00
$1,500.00
3' BHQ1
5' FAM
$110.00
$125.00
$160.00
$270.00
$810.00
$1,620.00
5' HEX
$110.00
$125.00
$160.00
$270.00
$810.00
$1,620.00
5' JOE
$198.00
$240.00
$260.00
$395.00
$960.00
$1,920.00
Others
Please quote

Multiple Labeling

GenScript can also incorporate more than one label within a single oligo. Please complete a quote for multiple labeling.

Delivery Specifications:

Turnaround:
5-7 business days

Deliverables:
  • Your desired oligonucleotides in tubes
  • Certificate of analysis (COA)
  • MS report
  • HPLC report
  • CGE report

Quotations and Ordering

Our customer service representatives are available 24 hours Monday through Friday. You may contact us anytime for assistance.