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Custom RNA Oligos

Custom RNA Oligos

  oligo services quotation

Synthetic RNA is widely used in research applications as an important tool for gene functional analysis and the development of novel therapeutic strategies. GenScript provides high-quality and cost-effective custom RNA oligos with flexible synthesis scales to meet researchers' different needs. Unmodified RNA, RNA with modifications, chimeric oligonucleotides with mixed DNA and RNA bases, 2'-OMe-RNA, 2'-F-RNA, and other antisense RNAs are available at your specific request. To ensure that the RNA oligos are of highest quality, all RNA oligonucleotides are identified by MALDI-TOF(matrix-assisted laser desorption ionization–time-of-flight) mass spectrometry, to meet QC specifications, the measured mass must not different from the calculated mass by more than 4 atomic mass units. The purity of the RNA is analyzed by HPLC.

Competitive Advantages:

  • Comprehensive Backbones: RNA, 2'-OMe-RNA, 2'-F-RNA and other analogs
  • Flexible Synthesis Scales: 50 nmol, 100 nmol, 200 nmol, 1 µmol, 5 µmol, and 10 µmol. Bulk orders are available upon request
  • Experienced Team: scientists and staff with over 20 years of experience in oligo synthesis and modifications
  • High Quality: ISO9001 certificated, comprehensive quality control reports (HPLC, MS, CGE)
  • Cost Effective: competitive prices, especially at 50 nmol scale


  • Services
  • Modifications/Labeling
  • Delivery Specifications

RNA Oligo Synthesis:

GenScript provides comprehensive RNA backbones with flexible synthesis scales for your antisense studies.

Price per Base for RNA oligo
RNA Oligos
50 nmol
100 nmol
200 nmol
1 µmol
5 µmol
10 µmol
RNA
$5.00
$6.00
$7.50
$16.00
$55.00
$105.00
2'-OMe-RNA
$6.80
$8.00
$12.00
$18.00
$80.00
$150.00
2'-F-RNA
$80.00
$100.00
$200.00
$260.00
Quote
Quote
Chimeric DNA
$0.39
$0.45
$0.79
$1.75
$8.19
$14.99
Annealing
(Price per Duplex)
$22.50
$26.50
$36.00
$41.00
Quote
Quote
* Prices are available from 15-50 bases
* Please inquire for other analogs.

Modification/Labeling:

GenScript provides a wide variety of modifications for your individual research need. The modifications range from

  • General modifications such as modified bases, phosphorylation, thiolation, linkages, etc.
  • Labeling such as fluorescent/non-fluorescent dye labeling, dual-labeled and multiple labeling
  • Backbone modifications such as DNA containing thiophosphodiester linkages.

Purification:

GenScript's RNase-Free HPLC purification is carefully performed in an RNase-free environment. Reagents, equipment and processing are all constantly monitored for RNase contamination.

Pricing for RNA Oligo Purification
Purification
50 nmol
100 nmol
200 nmol
1 µmol
5 µmol
10 µmol
Desalt
free
free
free
free
free
free
RNase Free HPLC
$65.00
$65.00
$92.00
$145.00
$310.00
$550.00

Guaranteed Purification Yield for Unmodified RNA Oligo
Purification
50 nmol
100 nmol
200 nmol
1 µmol
5 µmol
10 µmol
Desalt
3 OD
6 OD
10 OD
45 OD
200 OD
400 OD
RNase Free HPLC
1 OD
2 OD
4 OD
20 OD
100 OD
200 OD
*Yield guarantee only for 15-50 bases in length.
*Modifications can affect yield.

Additional Service:

Extra $0.20/tube for aliquoting into over 5 tubes.

Modification/Labeling

Modified Bases Phosphorothioates Phosphorylation Spacers
Amino Linkers Disulfide Linkers Biotin Digoxin
Fluorophores Quenchers

Classification Modification 50 nmol 100 nmol 200 nmol 1 µmol 5 µmol 10 µmol
Modified Bases
($/modified base)
dI
$6.00
$7.00
$9.00
$13.50
$27.00
$54.00
dU
$6.00
$7.00
$9.00
$13.50
$27.00
$54.00
SPO3
$2.60
$3.25
$3.25
$4.50
$18.00
$27.00
5' PO4
$15.00
$18.00
$23.00
$39.00
$78.00
$155.00
3' PO4
$17.60
$22.00
$28.00
$44.00
$110.00
$220.00
3' or 5' NH2 C3
$18.00
$21.00
$26.00
$44.00
$90.00
$180.00
5' NH2 C6
$18.00
$21.00
$26.00
$44.00
$90.00
$180.00
3' NH2 C7
$18.00
$21.00
$26.00
$44.00
$90.00
$180.00
5' NH2 C12
$45.00
$48.00
$62.00
$94.00
$190.00
$380.00
NH2 C6 dT
$95.00
$110.00
$135.00
$200.00
$400.00
$800.00
3' C3 S-S
$68.00
$85.00
$85.00
$130.00
$335.00
$670.00
5' C6 S-S
$88.00
$110.00
$110.00
$175.00
$350.00
$700.00
Spacer C3
$30.00
$35.00
$45.00
$67.50
$135.00
$270.00
Spacer C6
$56.00
$70.00
$90.00
$100.00
$200.00
$400.00
Spacer 9
$30.00
$35.00
$45.00
$67.50
$135.00
$270.00
Spacer 18
$45.00
$50.00
$55.00
$80.00
$160.00
$320.00
dSpacer
$60.00
$75.00
$90.00
$135.00
$270.00
$540.00
5' Biotin
$30.00
$36.00
$45.00
$90.00
$185.00
$370.00
3' Biotin
$45.00
$52.50
$66.00
$102.00
$260.00
$520.00
5' Biotin TEG
$49.60
$62.00
$78.00
$110.00
$270.00
$540.00
3' Biotin TEG
$47.00
$55.00
$70.00
$105.00
$237.50
$475.00
5' Dual Biotin
$140.00
$175.00
$175.00
$270.00
$410.00
$820.00
5' or Internal Biotin dT
$124.00
$155.00
$155.00
$245.00
$620.00
$1,240.00
5' PC Biotin
$100.00
$125.00
$125.00
$240.00
$600.00
$1,200.00
3' or 5' Digoxin
$85.00
$100.00
$105.00
$160.00
$600.00
$1,200.00
5' Cy3
$62.00
$70.00
$90.00
$135.00
$405.00
$810.00
5' Cy5
$62.00
$70.00
$90.00
$135.00
$405.00
$810.00
5' FAM
$48.00
$55.00
$70.00
$135.00
$270.00
$540.00
3' FAM
$48.00
$55.00
$70.00
$135.00
$335.00
$670.00
5' HEX
$48.00
$55.00
$70.00
$135.00
$270.00
$540.00
3' TET
$48.00
$55.00
$70.00
$135.00
$270.00
$540.00
3' or 5' TAMRA
$80.00
$90.00
$112.50
$175.00
$350.00
$700.00
Internal TAMRA
$155.00
$180.00
$205.00
$360.00
$650.00
$1,300.00
3' DABCYL
$62.00
$70.00
$90.00
$135.00
$345.00
$690.00
Ferrocene
$80.00
$100.00
$125.00
$190.00
$760.00
$1,520.00
Please quote

Delivery Specifications:

Turnaround:
5-10 business days

Deliverables:
  • Your desired oligonucleotides in tubes
  • Certificate of analysis (COA)
  • MS report
  • HPLC report
  • CGE report
  • Quotations and Ordering:

    For quotations, please use our secured Online Quotation/Ordering system. However, you may also contact us by email, phone (1-732-885-9188) or fax (1-732-210-0262).

    Oligo Online Quotation/Ordering

    Orders can be placed directly through our secured Online Quotation/Ordering system with a formal PO (Purchase Order) or credit card.

    For batch orders, please download and complete our Quick Quotation Request and send it to us via email or fax.

    Our customer service representatives are available 24 hours Monday through Friday. You may contact us anytime for assistance.