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GnRHR Antibody, mAb, Mouse
Full Name
GnRHR Antibody, mAb, Mouse GnRHR Antibody, mAb, Mouse
Abbreviated name-1
Mouse Anti-GnRHR mAb; Anti GnRHR (monoclonal)
Documents
Description
Gonadotropin Releasing Hormone (GnRH) is down-regulated by hCG and believed to be an autocrine factor that regulates the ovary. The Gonadotropin Releasing Hormone Receptor (GnRHR) is synthesized in the pituitary gland. Activin A has been shown to stimulate the synthesis of GnRHR, illustrating a possible mechanism for the modulation of gonadotropin responsiveness to GnRH.
Ig Subclass
Mouse Monoclonal (IgG)
Storage
The antibody will remain stable for one year from the date of shipment if stored at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap and avoid repeated freezing and thawing. Aliquots will remain stable for three months if stored at 4°C.
Specificity
Recognize specifically GnRH receptor from human and other species not tested
Formulation
1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid
Immunogen
A mixture of peptides from different regions of GnRH receptor protein
Clone ID
A00086.01
Purification Method
Immunoaffinity purification
Applications
Western blot: 1:1,000
Immunohistochemistry: 1:200
This antibody reacts with GnRH receptors in the anterior pituitary. GnRH functions as a stimulator of gonadotrophs to release luteinizing hormone (LH) and follicle stimulating hormone (FSH).
Conjugation
Unconjugated
Species Reactivity
Human
Host Species
Mouse
Antigen Species
Human
Note
Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage.
Technical Manual
ELISA Protocol(pdf)
Western Blot Protocol(pdf)
FACS Protocol(pdf)
IHC Protocol(pdf)
IP Protocol(pdf)
Citation
Pask AJ, et al. A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Mol. Endocrinol. Apr 2005; 19 (4): 972-981.

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