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LPL Antibody, mAb, Mouse

*This product has been discontinued! *
Product Aliases Mouse Anti LPL (monoclonal); Mouse Anti LPL
Description Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF) secretion and induction of vascular smooth muscle cell proliferation.
Immunogen Human LPL whole protein
Host Species Mouse
Conjugation Unconjugated
Purification Method Immunoaffinity purification

Formulation 1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid
Clone ID A00090.01
Ig Subclass Mouse IgG1
Specificity Recognize specifically LPL from human and bovine
Storage The antibody remains stable for one year from date of shipment if stored at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will remain stable at 4°C for three months.
Note Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage.

Western blot: 1:100
ELISA: 1:200-500 in lipid metabolic research

Yin B, et al. Lipoprotein lipase regulates Fc receptor-mediated phagocytosis by macrophages maintained in glucose-deficient medium. J. Clin. Invest. Aug 1997; 100(3): 649-657.

You can visit "Citations Database" for more citations. Ikeda Y, et al. A sandwich-enzyme immunoassay for the quantification of lipoprotein lipase and hepatic triglyceride lipase in human postheparin plasma using monoclonal antibodies to the corresponding enzymes. J. Lipid Res. Oct 1990; 31 (10): 1911-1924.

You can visit "Citations Database" for more citations. Pyle DM.,et al. IgE cross-linking critically impairs human monocyte function by blocking phagocytosis.J Allergy Clin Immunol.2013Feb;131(2):491-500

You can visit "Citations Database" for more citations. Sun L.,et al. Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.PLoS One.2012Feb;7(2):e30802

You can visit "Citations Database" for more citations.

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