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Apo CI Antibody, pAb, Rabbit
Full Name
Apo CI Antibody, pAb, Rabbit Apo CI Antibody, pAb, Rabbit
Abbreviated name-1
Rabbit Anti-Human Apo CI pAb; Anti Human Apo CI
Documents
Description
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein.
At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A-1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).
Ig Subclass
Rabbit IgG
Storage
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stale at 4°C for 3 months.
Specificity
Specially binds to human apo CI
Formulation
1 mg/ml, PBS, pH 7.4 with 0.05% sodium azide.
Immunogen
Apo CI recombinant protein
Purification Method
Immunoaffinity purification
Applications
Western blot: 1:2,500-1:10,000
ELISA: 1:2,500-1:10,000
Conjugation
Unconjugated
Species Reactivity
Human
Host Species
Rabbit
Antigen Species
Human
Note
Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage.
Technical Manual
ELISA Protocol(pdf)
Western Blot Protocol(pdf)
FACS Protocol(pdf)
IHC Protocol(pdf)
IP Protocol(pdf)
Citation
Taddei-Peters WC, et al. Quantification of lipoprotein(a) particles containing various apolipoprotein(a) isoforms by a monoclonal anti-apo(a) capture antibody and a polyclonal anti-apolipoprotein B detection antibody sandwich enzyme immunoassay. Clin. Chem. Jul 1993; 39(7): 1382-1389.

Clavey V, et al. Modulation of lipoprotein B binding to the LDL receptor by exogenous lipids and apolipoproteins CI, CII, CIII, and E. Arterioscler Thromb Vasc. Biol. Jul 1995; 15(7): 963-971.

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