Ubiquitin Antibody, pAb, Rabbit

Ubiquitin is a highly conserved protein of about 8,500 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimers disease, Lewy bodies seen in Parkinsons disease, and Pick bodies found in Picks disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.