Catalog Products » Antibodies » Primary Antibodies » Phospho-Specific Antibodies » AMPKα1 Antibody (Phospho-Ser487), pAb, Rabbit
Manual
Manual
COAs

AMPKα1 Antibody (Phospho-Ser487), pAb, Rabbit

*This product has been discontinued!*
Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-COA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-COA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
A00345
Ask us a question
Overview
Specificity GenScript Rabbit Anti-AMPKα1 (Phospho-Ser487) Polyclonal Antibody detects endogenous levels of AMPKα1 only when phosphorylated at serine 487.
Host Species Rabbit
Immunogen Synthesized phosphopeptide derived from human AMPKα1 around the phosphorylation site of Serine 487 (S-G-SP-V-S)
Species Reactivity Human, Mouse, Rat
Back

Properties
Concentration 1 mg/ml in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide, and 50% glycerol
Purification GenScript Rabbit Anti-AMPKα1 (Phospho-Ser487) Polyclonal Antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide is removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Back

Background
Target Background Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-COA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-COA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
Synonyms AMPKα1 Antibody (Phospho-Ser487), pAb, Rabbit;
Back