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β-Amyloid Antibody (25-35), pAb, Rabbit

Cat. No.	Name	Size	Price
A00687-200	β-Amyloid Antibody (25-35), pAb, Rabbit	200 μg(5x40μg)	$225
A00687-40	β-Amyloid Antibody (25-35), pAb, Rabbit	40 μg	$50

Full Name

β-Amyloid Antibody (25-35), pAb, Rabbit

Abbreviated name-1

Rabbit Anti β-Amyloid (25-35) pAb; Anti β-Amyloid (25-35) pAb

Documents
Document-MSDS: 8072_20081107013522.PDF (PDF)
Document-MSDS: 3739_20080118034804.PDF (PDF)
Figures
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Reference

Description

A number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimers Disease. βAPP is cleaved sequentially by the proteolytic enzymes β-secretase and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42(43) and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides can bind to scavenger receptors and the receptor for advanced glycation endproducts. Aβ peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme. Extracellular accumulation of Aβ leads to formation of aggregates, fibrils, and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimerâs disease. β-Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimers disease.

Ig Subclass

Rabbit IgG

Storage

The antibody is stable for 2-3 weeks if stored at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Specificity

GenScript Rabbit Anti-β-Amyloid (25-35) Polyclonal Antibody detects human β-amyloid 25-35 and β-amyloid 1-40 and does not react with β-amyloid 1-42.

Concentration

See label for antibody concentration
Buffer: PBS, pH 7.4, containing 30% glycerol and 0.02% sodium azide

Immunogen

Synthetic peptide corresponding to amino acids 25-35 of human β-Amyloid conjugated to KLH

Purification Method

Immunoaffinity chromatography

Applications

Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA: 0.05-0.2 µg/ml
Western blot: 0.5-2.0 µg/ml
Other applications: user-optimized

Conjugation

Unconjugated

Species Reactivity

Human

Host Species

Rabbit

Antigen Species

Human

Note

Small volume of antibody will occasionally become entrapped in the cap of the vial during shipment and storage. Before use, centrifuge the vial briefly to bring down any liquid in the cap.

Technical Manual

TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)


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