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β-Amyloid Antibody (1-40), pAb, Rabbit

Cat. No.	Name	Size	Price
A00688-200	β-Amyloid Antibody (1-40), pAb, Rabbit	200 μg(5x40μg)	$225
A00688-40	β-Amyloid Antibody (1-40), pAb, Rabbit	40 μg	$50

Full Name

β-Amyloid Antibody (1-40), pAb, Rabbit

Abbreviated name-1

Rabbit Anti β-Amyloid (1-40) pAb; Aβ 1-40

Documents
Document-MSDS: 4214_20080228035753.PDF (PDF)
Document-MSDS: 3739_20080118034804.PDF (PDF)
Figures
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Reference

Description

A number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimers Disease. βAPP is cleaved sequentially by the proteolytic enzymes β-secretase and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42(43) and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides can bind to scavenger receptors and the receptor for advanced glycation endproducts. Aβ peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme. Extracellular accumulation of Aβ leads to formation of aggregates, fibrils, and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimerâs disease. β-amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimers disease.
The rabbit anti-β-amyloid 1-40 antibody is developed in rabbit using a synthetic peptide corresponding to amino acids 1-40 of β-amyloid conjugated to KLH.
This polyclonal antibody is highly purified from rabbit antiserum by immunoaffinity chromatography and is supplied as a 100 μl aliquot at a concentration of 1 mg/ml in PBS, pH7.4, containing 0.02% sodium azide.

Ig Subclass

Rabbit IgG

Storage

The antibody is stable for 2-3 weeks if stored at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Specificity

This antibody is specific to human β-amyloid 1-40. Weak cross-reactivity is observed with human β-amyloid 1-42.

Concentration

1 mg/ml in PBS, pH 7.4, containing 0.02% sodium azide

Immunogen

A synthetic peptide corresponding to amino acids 1-40 of β-amyloid conjugated to KLH

Purification Method

Immunoaffinity chromatography

Applications

The investigator must determine the ideal working concentration for each specific application. We have not yet determined the suitability of this antibody for applications other than those listed below. The ideal working concentration must take into account such factors as secondary antibody affinity, antigen concentration, sensitivity of the detection method, temperature, and the length of the incubations. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA: 0.05-0.5 µg/ml
Western blot: 0.1-1.0 µg/ml
Immunofluorescence: 5-20 µg/ml
Other applications: user-optimized

Conjugation

Unconjugated

Species Reactivity

Human

Host Species

Rabbit

Antigen Species

Human

Note

Small volume of antibody will occasionally become entrapped in the cap of the vial during shipment and storage. Before use, centrifuge the vial briefly to bring down any liquid in the cap.

Technical Manual

TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)


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