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Serum Amyloid P Antibody, pAb, Rabbit

Cat. No.	Name	Size	Price
A00701-200	Serum Amyloid P Antibody, pAb, Rabbit	200 μg(5x40μg)	$225
A00701-40	Serum Amyloid P Antibody, pAb, Rabbit	40 μg	$50

Full Name

Serum Amyloid P Antibody, pAb, Rabbit

Abbreviated name-1

Rabbit Anti-Serum Amyloid P pAb;

Documents
Document-MSDS: 4217_20080228040830.PDF (PDF)
Document-MSDS: 3739_20080118034804.PDF (PDF)
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Reference

Description

Serum amyloid P component (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits (such as senile plaque and neurofibrially tangles in Alzheimers patients), and this is probably due to its specific calcium-dependent binding to motifs, which are present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits. It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T-lymphocytes, or B-lymphocytes. SAP production can be induced by exposure to IL-1, IL-6, and IFN-beta. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients.
GenScript Rabbit Anti-Serum Amyloid P Polyclonal Antibody is developed in rabbit using a synthetic peptide corresponding to residues near the N-terminus of human serum amyloid P-component conjugated to KLH.

Ig Subclass

Rabbit IgG

Storage

The antibody is stable for 2-3 weeks if stored at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Specificity

GenScript Rabbit Anti-Serum Amyloid P Polyclonal Antibody is specific to human and mouse serum amyloid P component. It has not yet been tested in other species.

Concentration

1 mg/ml in PBS, pH7.4, containing 0.02% sodium azide

Immunogen

A synthetic peptide corresponding to residues near the N-terminus of human serum amyloid P-component conjugated to KLH

Purification Method

Immunoaffinity chromatography

Applications

Working concentrations for specific applications should be determined by the investigator. Appropriate concentrations will be affected by several factors, including secondary antibody affinity, antigen concentration, sensitivity of detection method, temperature, and length of incubations, etc. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA: 0.05-0.2 µg/ml
Western blot: 0.1-1.0 µg/ml
Other applications: user-optimized

Conjugation

Unconjugated

Host Species

Rabbit

Antigen Species

Human

Note

Small volume of antibody will occasionally become entrapped in the cap of the vial during shipment and storage. Before use, centrifuge the vial briefly to bring down any liquid in the cap.

Technical Manual

TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)


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