IFN-γ Antibody, mAb, Mouse

*This product has been discontinued!*

Interferon-γ (IFN-γ) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells. Its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites, and viruses. Takayanagi et al. (2000) demonstrated that IFN-γ strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.

Cat. No.	A00731
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Overview Properties Background

Overview

Specificity	Truncated IFN-γ recombinant protein (WB), human IFN-γ recombinant protein (ELISA)
Host Species	Mouse
Immunogen	Ni-NTA purified recombinant human IFN-γ expressed in E. coli strain BL21 (DE3)

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Properties

Concentration	1 mg/ml in 10 mM PBS (pH 7.6) and 0.02% sodium azide
Purification	GenScript Mouse Anti-IFN-γ Monoclonal Antibody is purified by protein A affinity chromatography.
Clone ID	A00731.01

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Background

Target Background

Interferon-γ (IFN-γ) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells. Its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites, and viruses. Takayanagi et al. (2000) demonstrated that IFN-γ strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.

Synonyms

Mouse Anti-IFN-γ mAb;

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