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CD14 Antibody, mAb, Mouse

*This product has been discontinued!*
CD14 antigen is a GPI-linked glycoprotein with a molecular weight of 55,000 Da. The CD14 antigen is expressed on cells of the myelomonocytic lineage including monocytes, macrophages, and Langerhans cells. Low expression is observed on neutrophils and on human B cells. CD14 antigen is a receptor for bacterial lipopolysaccharide (LPS, endotoxin) and the lipopolysaccharide binding protein (LBP). LBP and CD14 antigen serve two physiological roles. These proteins act as opsonin and opsonic receptors, respectively, promoting the phagocytic uptake of bacteria and LPS-coated particles by macrophages.
A00741
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Overview
Specificity Human lymph node tissue(IHC), human CD14 recombinant protein (ELISA)
Host Species Mouse
Immunogen Ni-NTA purified recombinant human CD14 expressed in E. coli strain BL21 (DE3)
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Properties
Concentration 1 mg/ml in 10 mM PBS (pH 7.6) and 0.02% sodium azide
Purification GenScript Mouse Anti-Human CD14 Monoclonal Antibody is purified by protein G affinity chromatography and resuspended in 10 mM PBS (pH 7.6) and 0.02% sodium azide. No reconstitution is necessary.
Clone ID A00741.01
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Background
Target Background CD14 antigen is a GPI-linked glycoprotein with a molecular weight of 55,000 Da. The CD14 antigen is expressed on cells of the myelomonocytic lineage including monocytes, macrophages, and Langerhans cells. Low expression is observed on neutrophils and on human B cells. CD14 antigen is a receptor for bacterial lipopolysaccharide (LPS, endotoxin) and the lipopolysaccharide binding protein (LBP). LBP and CD14 antigen serve two physiological roles. These proteins act as opsonin and opsonic receptors, respectively, promoting the phagocytic uptake of bacteria and LPS-coated particles by macrophages.
Synonyms Mouse Anti-Human CD14 mAb;
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