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AURKB Antibody, mAb, Mouse

*This product has been discontinued!*
AURKB (aurora kinase B, AIK2 or aurora-B), a 344-amino acid protein of about 39,000 Da, localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates chromosomal segregation during mitosis and meiosis. It may regulate several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis. It is also a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts are present at high levels in human thymus and fetal liver. ARK-2 protein levels are maximal during both S and G2/M phases.
A00780
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Overview
Specificity Truncated AURKB recombinant protein / SK-N-SH cell lysate (WB), AURKB recombinant protein (ELISA)
Host Species Mouse
Immunogen Ni-NTA purified truncated recombinant AURKB expressed in E. coli strain BL21 (DE3)
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Properties
Concentration 1 mg/ml in 10 mM PBS (pH 7.6) and 0.02% sodium azide
Clone ID A00780.01
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Background
Target Background AURKB (aurora kinase B, AIK2 or aurora-B), a 344-amino acid protein of about 39,000 Da, localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates chromosomal segregation during mitosis and meiosis. It may regulate several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis. It is also a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts are present at high levels in human thymus and fetal liver. ARK-2 protein levels are maximal during both S and G2/M phases.
Synonyms Mouse Anti-AURKB mAb;
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Citations
Izumi Sato, et al. MicroRNA Let-7c Contributes to Paclitaxel Resistance via Aurora-B in Endometrial Serous Carcinoma. Tohoku J Exp Med. (2020)