||Mouse Anti-SNCA mAb;
||Alpha-synuclein (SNCA), with 140-amino acid protein (about 15,000 Da), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
||Ni-NTA purified truncated recombinant SNCA expressed in E. coli strain BL21 (DE3).
||1 mg/ml in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
||Truncated SNCA recombinant protein (WB), human SNCA recombinant protein (ELISA), human glioma tissue (IHC)
||This product remains stable for one to two weeks if stored at 2°C to 8°C. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. Use before is one year from the date of receipt.
||Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage.
J. Johnson, S. M. Hague, M. Hanson
Neurology, Aug 2004; 63: 554 - 556
Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie
Protein Pept Lett. 2006;13(4):385-90.