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SNCG Antibody, mAb, Mouse

Full Name

Abbreviated name-1

Mouse Anti-SNCG mAb;

Documents
Document-MSDS: 8225_20081113030152.PDF (PDF)
Document-MSDS: 3739_20080118034804.PDF (PDF)
Figures
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Reference
Haiyan Liu, Wei Liu, Yinwei Wu Cancer Res. 2005 Sep 1;65(17):7635-43 Irina Surgucheva , Belinda McMahon , Andrei Surguchov Cell Motil Cytoskeleton. 2006 May 26

Description

SNCG (also designated gamma-synuclein or breast cancer-specific protein 1), with 127-amino acid protein (about 14,000 Da), belongs to the synuclein family, which also includes alpha- and beta- synuclein. Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals, while SNCG is also expressed in many other non-neuronal tissues. SNCG is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.

Ig Subclass

IgG1

Storage

This product remains stable for one to two weeks if stored at 2°C to 8°C. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. Use before is one year from the date of receipt.

Specificity

Truncated SNCG recombinant protein (WB), human SNCG recombinant protein (ELISA), Human ovary carcinoma / breast carcinoma (IHC)

Concentration

0.3 mg/ml in 10 mM PBS (pH 7.6), 0.02% sodium azide and 50% glycerol

Immunogen

Ni-NTA purified truncated recombinant SNCG expressed in E. coli strain BL21 (DE3)

Purification Method

SNCG is purified by protein A affinity chromatography.

Applications

Western blot: 1:500-1:2,000
IHC(P): 1:500-1:2,000
IHC(F): 1:500-1:2,000
ELISA: Propose dilution 1:10,000
Determinining optimal working dilutions by titration test

Host Species

Mouse

Antigen Species

Human

Note

Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage.

Technical Manual

TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)


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