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SNCG Antibody, mAb, Mouse

*This product has been discontinued!*
SNCG (also designated gamma-synuclein or breast cancer-specific protein 1), with 127-amino acid protein (about 14,000 Da), belongs to the synuclein family, which also includes alpha- and beta- synuclein. Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals, while SNCG is also expressed in many other non-neuronal tissues. SNCG is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.
A00812
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Overview
Specificity Truncated SNCG recombinant protein (WB), human SNCG recombinant protein (ELISA), Human ovary carcinoma / breast carcinoma (IHC)
Host Species Mouse
Immunogen Ni-NTA purified truncated recombinant SNCG expressed in E. coli strain BL21 (DE3)
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Properties
Concentration 0.3 mg/ml in 10 mM PBS (pH 7.6), 0.02% sodium azide and 50% glycerol
Purification SNCG is purified by protein A affinity chromatography.
Clone ID A00812.01
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Background
Target Background SNCG (also designated gamma-synuclein or breast cancer-specific protein 1), with 127-amino acid protein (about 14,000 Da), belongs to the synuclein family, which also includes alpha- and beta- synuclein. Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals, while SNCG is also expressed in many other non-neuronal tissues. SNCG is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.
Synonyms Mouse Anti-SNCG mAb;
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