CIB1 Antibody, mAb, Mouse

CIB1 (also designated calcium and integrin binding 1 or calmyrin), with 191-amino acid protein (about 21,000 Da), belongs to the calcium-binding protein family. CIB1 is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. CIB1 is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alpha (IIb) beta (3) integrin and several serine/threonine kinases and potentially modulates their function. CIB1 regulates platelet aggregation in hemostasis through a specific interaction with the alpha (IIb) cytoplasmic domain of platelet integrin alpha (IIb) beta (3). CIB1 is also ubiquitously expressed activating and inhibiting protein ligand of the InsP3R.