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Desmin Antibody, mAb, Mouse

*This product has been discontinued! *
Product Aliases Mouse Anti-Desmin mAb;
Description Desmin (DES), with 470-amino acid protein (about 52,000 Da), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.
Immunogen Ni-NTA purified truncated recombinant Desmin expressed in E. coli strain BL21 (DE3)
Host Species Mouse

Formulation 1 mg/ml in 10 mM PBS (pH 7.6) and 0.02% sodium azide
Clone ID A00819.01
Ig Subclass IgG1
Specificity Truncated Desmin recombinant protein (WB), human Desmin recombinant protein (ELISA), human smooth muscle sarcoma (IHC)
Storage This product remains stable for one to two weeks if stored at 2°C to 8°C. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. Use before is one year from the date of receipt.
Note Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage.

Western blot:1:1,000-1:2,000
IHC(F): 1:1,000-1:2,000
ELISA: Propose dilution 1:10,000
Determining optimal working dilutions by titration test
Technical Manual ELISA Protocol(pdf)
Western Blot Protocol(pdf)
FACS Protocol(pdf)
IHC Protocol(pdf)
IP Protocol(pdf)

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