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PEN2 Antibody, pAb, Rabbit

Cat. No.	Name	Size	Price
A00882-200	PEN2 Antibody, pAb, Rabbit	200 μg(5x40μg)	$225
A00882-40	PEN2 Antibody, pAb, Rabbit	40 μg	$50

Full Name

PEN2 Antibody, pAb, Rabbit

Abbreviated name-1

Rabbit Anti-PEN2 pAb;

Documents
Document-MSDS: 6906_20081019225359.PDF (PDF)
Document-MSDS: 3739_20080118034804.PDF (PDF)
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Reference

Description

Presenilin enhancer protein 2 (PEN2) is a 101-amino acid protein that traverses the membrane twice and it is the regulatory component of the multimeric gamma-secretase complex which also consists of presenilin, APH-1 and Nicastrin. The gamma-secretase complex catalyzes the cleavage of a number of integral membrane proteins including beta-amyloid precursor protein (APP), Notch protein, Erb4 and E-cadherin. The gamma-secretase complex cleaves the APP yielding amyloid beta peptide, which is the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. In addition, PEN2 is required for end proteolysis of presenilin and activation of the gamma-secretase.

GenScript Rabbit Anti-PEN2 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide derived from human PEN2.

Ig Subclass

Rabbit IgG

Storage

The antibody is stable for 2-3 weeks if stored at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Specificity

GenScript Rabbit Anti-PEN2 Polyclonal Antibody can be used to detect human PEN2. It is predicted to react with mouse, rat and bovine PEN2 according to sequence homology.

Concentration

0.5 mg/ml in PBS, pH 7.4, containing 30% glycerol and 0.02% sodium azide

Immunogen

Synthetic peptide (KLH-conjugated) corresponding to human PEN2

Purification Method

Immunoaffinity chromatography

Applications

Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA: 0.05-0.2 µg/ml
Western blot: 1-2 µg/ml
Other applications: user-optimized

Conjugation

Unconjugated

Host Species

Rabbit

Antigen Species

Human

Note

Small volume of antibody will occasionally become entrapped in the cap of the vial during shipment and storage. Before use, centrifuge the vial briefly to bring down any liquid in the cap.

Technical Manual

TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)


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