PKA RIIβ Antibody, pAb, Rabbit

The cAMP-dependent protein kinase (PKA) is a critical kinase involved in numerous biological functions. The PKA holoenzyme is composed of two regulatory and two catalytic subunits, designated PKA R and PKA C, respectively. PKA regulatory (PKA R) subunits exist as two classes, RI and RII, with each class containing two isoforms, α and β. Three catalytic subunit isoforms, Cα, Cβ, and Cγ, have been identified. The PKA R subunits allow a range of modifying agents to influence PKA activity and localization, and are found in different levels in a tissue-specific manner. Upon PKA R subunit binding to the second messenger cAMP, active PKA C subunits are released, initiating a phosphorylation cascade that regulates such cellular functions as metabolism, ion transport, and gene transcription.GenScript Rabbit Anti-PKA RIIβ Polyclonal Antibody is developed in rabbit using a synthetic peptide (KLH-coupled) derived from human PKA regulatory IIβ subunit (PKA RIIβ).