Runx3 is also known as Core-binding factor, CBF-alpha 3, acute myeloid leukemia 2 protein, Oncogene AML-2, polyomavirus enhancer-binding protein 2 alpha C subunit, PEBP2-alpha C, PEA2-alpha. It binds to the core site of murine leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. Runx3 may be involved in the control of cellular proliferation and/or differentiation. GenScript Rabbit Anti-Runx3 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide of mouse Runx3.
Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product. ELISA: 0.03-1 µg/ml Western blot: 1.0 µg/ml Other applications: user-optimized