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CCR5 Antibody, pAb, Rabbit


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A00979-40 CCR5 Antibody, pAb, Rabbit
40 μg
$99.00



Abbreviated name-1 Rabbit Anti-CCR5 pAb;
Description The CC chemokine receptor 5 (CCR5) is a member of the CC chemokine receptor family. It has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 is a receptor for a number of inflammatory CC chemokines including MIP-1-alpha, MIP-1-beta and RANTES. It transduces a signal by increasing the intracellular calcium ion level and may play a role in the control of granulocytic lineage proliferation or differentiation. It also acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. CCR5 is highly expressed in spleen, thymus, and also in the myeloid cell line THP-1, the promyeloblastic cell line KG-1A and on the CD4+ and CD8+ T-cells. Moreover, recent studies have highlighted the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer.
GenScript Rabbit Anti-CCR5 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide derived from extracellular domain of human CCR5.
Immunogen KLH-coupled synthetic peptide derived from extracellular domain of human CCR5.
Host Species Rabbit
Conjugation Unconjugated
Purification Method Immunoaffinity chromatography

Formulation 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Ig Subclass Rabbit IgG
Specificity GenScript Rabbit Anti-CCR5 Polyclonal Antibody detects human CCR5 protein. It has not yet been tested for other species.
Storage The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
Note Small volume of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.

Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA: 0.05-0.2 µg/ml
Immunohistochemistry: 5-10 µg/ml
Other applications: user-optimized
Technical Manual ELISA Protocol(pdf)
Western Blot Protocol(pdf)
FACS Protocol(pdf)
IHC Protocol(pdf)
IP Protocol(pdf)

CCR5 Antibody, PAb, Rabbit
CCR5 Antibody, PAb, Rabbit

Immunohistochemistry analysis of human spleen tissue slide (Paraffin embedded) using
Rabbit Anti-CCR5 Polyclonal Antibody (GenScript, A00979)

CCR5 Antibody, PAb, Rabbit
CCR5 Antibody, PAb, Rabbit

Immunohistochemistry negative control analysis of human spleen tissue slide (Paraffin embedded) using
Purified Rabbit IgG (Whole molecule) Control (GenScript, A01008)

CCR5 Antibody, PAb, Rabbit

CCR5 Antibody, PAb, Rabbit

CCR5 Antibody, PAb, Rabbit

CCR5 Antibody, PAb, Rabbit

CCR5 Antibody, PAb, Rabbit

CCR5 Antibody, PAb, Rabbit

CCR5 Antibody, PAb, Rabbit




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