RAP1A and RAP1B Antibody, pAb, Rabbit

*This product has been discontinued!*

RAP1A and RAP1B belong to a family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the classical Ras proteins and have numerous structural features in common. Human RAP1B is 95% identical to RAP1A. It has been proposed that RAP1A and RAP1B may regulate RAS-mediated signalling and may also be involved in the regulation of integrin-mediated cell adhesion, although the mechanism of regulation is not known.GenScript Rabbit Anti-RAP1A and RAP1B Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide, purified from rabbit antiserum by immunoaffinity chromatography, and supplied as 40 µg aliquot at concentration of 0.5 mg/ml.

Cat. No.	A01047
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	Reacts with human RAP1A and RAP1B. Sequence homology predicts that it will also react with mouse, rat, bovine, chicken, common carp, zebrafish and African clawed frog RAP1A and RAP1B.
Host Species	Rabbit
Immunogen	Synthetic peptide (KLH-conjugated) of human RAP1A and RAP1B

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Properties

Concentration	1 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

RAP1A and RAP1B belong to a family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the classical Ras proteins and have numerous structural features in common. Human RAP1B is 95% identical to RAP1A. It has been proposed that RAP1A and RAP1B may regulate RAS-mediated signalling and may also be involved in the regulation of integrin-mediated cell adhesion, although the mechanism of regulation is not known.
GenScript Rabbit Anti-RAP1A and RAP1B Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide, purified from rabbit antiserum by immunoaffinity chromatography, and supplied as 40 µg aliquot at concentration of 0.5 mg/ml.

Synonyms

Rabbit Anti-RAP1A and RAP1B pAb;

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Citations

1. Wang J, et al. Neutrophil infiltration during inflammation is regulated by PILR [alpha] via modulation of integrin activation. Nat Immunol. (2013-01)