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Tau Antibody (Ser262), pAb, Rabbit



Cat. No.
Name
Size   
Price
Selected
A01099-200
Tau Antibody (Ser262), pAb, Rabbit
200 μg(5x40μg)
$225
A01099-40
Tau Antibody (Ser262), pAb, Rabbit
40 μg
$50
Tau Antibody (Ser262), pAb, Rabbitcustom antibody production
Tau Antibody (Ser<sup>262</sup>), pAb, Rabbit
Full Name Tau Antibody (Ser262), pAb, Rabbit
Abbreviated name-1
Rabbit Anti-Tau (Ser262) pAb;
Documents
Tau Antibody (Ser<sup>262</sup>), pAb, RabbitDocument-MSDS: 7217_20081023031659.PDF (PDF)
Tau Antibody (Ser<sup>262</sup>), pAb, RabbitDocument-MSDS: 3739_20080118034804.PDF (PDF)
Figures
Tau Antibody (Ser<sup>262</sup>), pAb, Rabbit zoomTau Antibody (Ser<sup>262</sup>), pAb, Rabbit
Tau Antibody (Ser<sup>262</sup>), pAb, Rabbit zoomTau Antibody (Ser<sup>262</sup>), pAb, Rabbit
Reference
Description
Tau is a microtubule-associated phosphoprotein (MAP) which is localized in neuronal axons. It promotes tubulin polymerization and stabilizes microtubules. Tau proteins constitute a family of six isoforms ranging from 352 to 441 amino acids. The tau variant differs from each other with the presence or absence of either three or four repeated regions near the carboxy terminal of the molecule and one or two inserts near the amino terminal.
Tau is hyperphosphorylated by ERK, GSK-3, TPKII, and CDK5. At least thirty phosphorylation sites have been described, including Thr39, Ser46, Thr50, Thr69, Thr153, Thr175, Thr181, Ser198, Ser199, Ser202, Thr205, Ser208, Ser210, Thr212, Ser214, Thr217, Thr231, Ser235, Ser237, Ser241, Ser262, Ser285, Ser305, Ser324, Ser352, Ser356, Ser396, Ser400, Thr403, Ser404, Ser409, Ser412, Ser413, Ser416, and Ser422. Specifically, TPKII phosphorylates serines 202 and 404. GSK-3β transfection phosphorylates serines 199, 202, 235, 396, 404 and 413, and threonines 205 and 231. These sites are among the major abnormal phosphorylation sites of Tau. Phosphorylation on these sites reduces the ability of a given Tau species to promote microtubule self-assembly. Hyperphosphorylated Tau is the major protein forming the paired helical filaments (PHFs), which further form the pathological neurofibrillary tangles leading to Alzheimer’s disease (AD). These PHFs are also found to be related to the lesions of other central nervous system disorders.
GenScript Rabbit Anti-Tau (Ser262) Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide corresponding to the residues surrounding the serine 262 of human Tau.
Ig Subclass
Rabbit IgG
Storage
The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
Specificity
GenScript Rabbit Anti-Tau (Ser262) Polyclonal Antibody detects endogenous levels of total Tau protein.
Concentration
0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Immunogen
Synthetic peptide (KLH-coupled) corresponding to residues surrounding the serine 262 of human Tau
Purification Method
Immunoaffinity chromatography
Reconstitution
Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Predicted Band Size
85 kD, 55 kD
Observed Band Size
85 kD, 55 kD
Applications
Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA: 0.05-0.2 µg/ml
Western blot: 0.5-2 µg/ml
Other applications: user-optimized
Conjugation
Unconjugated
Species Reactivity
Human, mouse
Host Species
Rabbit
Antigen Species
Human
Technical Manual
TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)
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1
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