Tau Antibody (Ser²⁶²), pAb, Rabbit

Tau is a microtubule-associated phosphoprotein (MAP) which is localized in neuronal axons. It promotes tubulin polymerization and stabilizes microtubules. Tau proteins constitute a family of six isoforms ranging from 352 to 441 amino acids. The tau variant differs from each other with the presence or absence of either three or four repeated regions near the carboxy terminal of the molecule and one or two inserts near the amino terminal.Tau is hyperphosphorylated by ERK, GSK-3, TPKII, and CDK5. At least thirty phosphorylation sites have been described, including Thr39, Ser46, Thr50, Thr69, Thr153, Thr175, Thr181, Ser198, Ser199, Ser202, Thr205, Ser208, Ser210, Thr212, Ser214, Thr217, Thr231, Ser235, Ser237, Ser241, Ser262, Ser285, Ser305, Ser324, Ser352, Ser356, Ser396, Ser400, Thr403, Ser404, Ser409, Ser412, Ser413, Ser416, and Ser422. Specifically, TPKII phosphorylates serines 202 and 404. GSK-3β transfection phosphorylates serines 199, 202, 235, 396, 404 and 413, and threonines 205 and 231. These sites are among the major abnormal phosphorylation sites of Tau. Phosphorylation on these sites reduces the ability of a given Tau species to promote microtubule self-assembly. Hyperphosphorylated Tau is the major protein forming the paired helical filaments (PHFs), which further form the pathological neurofibrillary tangles leading to Alzheimer’s disease (AD). These PHFs are also found to be related to the lesions of other central nervous system disorders.GenScript Rabbit Anti-Tau (Ser262) Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide corresponding to the residues surrounding the serine 262 of human Tau.