β-Catenin Antibody, pAb, Rabbit

*This product has been discontinued!*

β-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs play a role in mediating the adhesion between cells, signaling the presence of neighboring cells, and anchoring the actin cytoskeleton. In serving these roles, AJs also regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs.GenScript Rabbit Anti-β-Catenin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 700-750 of human β-Catenin protein (Swiss Prot: P35222).

Cat. No.	A01211
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	GenScript Rabbit Anti-β-Catenin Polyclonal Antibody detects endogenous levels of human β-catenin protein. Sequence homology predicts that it will also react with rat β-catenin.
Host Species	Rabbit
Immunogen	Synthetic peptide (KLH-coupled) within residues 700-750 of human β-Catenin protein (Swiss Prot: P35222)
Species Reactivity	Human. This product has not yet been tested with other species.

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

β-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs play a role in mediating the adhesion between cells, signaling the presence of neighboring cells, and anchoring the actin cytoskeleton. In serving these roles, AJs also regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs.
GenScript Rabbit Anti-β-Catenin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 700-750 of human β-Catenin protein (Swiss Prot: P35222).

Synonyms

Rabbit Anti β-Catenin Polyclonal Antibody;

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