Calbindin Antibody, pAb, Rabbit

*This product has been discontinued!*

Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27 kD protein induced by vitamin D in the duodenums of young birds. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains four active calcium-binding domains and two modified domains that presumably have lost their calcium-binding capacity. The neurons in the brains of patients with Huntington’s disease are calbindin-depleted.GenScript Rabbit Anti-Calbindin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from residues 150-200 of human calbindin protein (Swiss Prot: P05937).

Cat. No.	A01268
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	GenScript Rabbit Anti-Calbindin Polyclonal Antibody detects human calbindin protein. Sequence homology predicts that it will also to react with mouse and rat calbindin.
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide from residues 150-200 of human calbindin protein (Swiss Prot: P05937)
Species Reactivity	Human. This product has not yet been tested with other species.

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27 kD protein induced by vitamin D in the duodenums of young birds. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains four active calcium-binding domains and two modified domains that presumably have lost their calcium-binding capacity. The neurons in the brains of patients with Huntington’s disease are calbindin-depleted.

GenScript Rabbit Anti-Calbindin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from residues 150-200 of human calbindin protein (Swiss Prot: P05937).

Synonyms

Rabbit Anti-Calbindin Polyclonal Antibody;

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Citations

1. Russell DF, et al. Large-Scale Convergence of Receptor Cell Arrays Onto Afferent Terminal Arbors in the Lorenzinian Electroreceptors of Polyodon. Frontiers in neuroanatomy. (2020-01)
2. NairRemya R, et al. Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice. J. Neurosci. (2018-09)