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TDP43 Antibody, pAb, Rabbit

*This product has been discontinued!*
TDP43 (known as TARDBP, TAR DNA-binding protein 43) is a DNA and RNA-binding protein which regulates transcription and splicing. The deduced 414-amino acid TDP43 contains a ribonucleoprotein (RNP)-binding domain and a glycine-rich region. TDP43 protein is located at cell nuclear in normal condition. TDP43 promotes skipping of exon 9 of the CFTR gene and also inhibits human CFTR exon 9 splicing. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and amyotrophic lateral sclerosis (ALS). Under pathologic conditions in FTLD-U, TDP43 is likely to be eliminated from nuclei of ubiquitinated inclusion-bearing neurons, a consequence of which may be a loss of TDP43 nuclear functions. TDP43 has been implicated in AIDS disease.GenScript Rabbit Anti-TDP43 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from within residues 250-300 of human TDP43 protein (Swiss Prot: Q13148).
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Specificity GenScript Rabbit Anti-TDP43 Polyclonal Antibody detects endogenous levels of human, mouse and rat TDP43 protein.
Host Species Rabbit
Immunogen KLH-coupled synthetic peptide from within residues 250-300 of human TDP43 protein (Swiss Prot: Q13148).
Species Reactivity Human, mouse and rat. Reactivity to other species is not tested yet.
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Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification Immunoaffinity chromatography
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Target Background TDP43 (known as TARDBP, TAR DNA-binding protein 43) is a DNA and RNA-binding protein which regulates transcription and splicing. The deduced 414-amino acid TDP43 contains a ribonucleoprotein (RNP)-binding domain and a glycine-rich region. TDP43 protein is located at cell nuclear in normal condition. TDP43 promotes skipping of exon 9 of the CFTR gene and also inhibits human CFTR exon 9 splicing. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and amyotrophic lateral sclerosis (ALS). Under pathologic conditions in FTLD-U, TDP43 is likely to be eliminated from nuclei of ubiquitinated inclusion-bearing neurons, a consequence of which may be a loss of TDP43 nuclear functions. TDP43 has been implicated in AIDS disease.

GenScript Rabbit Anti-TDP43 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from within residues 250-300 of human TDP43 protein (Swiss Prot: Q13148).
Synonyms Rabbit Anti-TARDBP antibody;
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