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MELK Antibody, pAb, Rabbit

*This product has been discontinued!*
MELK (Maternal Embryonic Leucine zipper Kinase, Protein kinase PK38) is one member of the Snf1/AMPK related kinase family of serine/threonine kinases. MELK kinase contains an N-terminal serine/threonine kinase domain that includes all 12 typical catalytic subdomains, and a KA1 (kinase-associated) domain. It is implicated in stem cell renewal, cell cycle progression, and pre-m-RNA splicing. The kinase is also a marker for self-renewing multipotent neural progenitors in the developing forebrain. MERK phosphorylates zinc finger protein 622 (ZNF622) and may contribute to its redirection to the nucleus. MERK may be involved in the inhibition of spliceosome assembly during mitosis.GenScript Rabbit Anti-MELK Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human MELK. (Swiss Prot: Q14680).
A01390
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Overview
Specificity GenScript Rabbit Anti-MELK Polyclonal Antibody detects endogenous levels of human and mouse MELK protein.
Host Species Rabbit
Immunogen KLH-coupled synthetic peptide from C-terminal of human MELK (Swiss Prot: Q14680).
Species Reactivity Human and mouse. This product has not been tested with other species yet.
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Properties
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification Immunoaffinity chromatography
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Background
Target Background MELK (Maternal Embryonic Leucine zipper Kinase, Protein kinase PK38) is one member of the Snf1/AMPK related kinase family of serine/threonine kinases. MELK kinase contains an N-terminal serine/threonine kinase domain that includes all 12 typical catalytic subdomains, and a KA1 (kinase-associated) domain. It is implicated in stem cell renewal, cell cycle progression, and pre-m-RNA splicing. The kinase is also a marker for self-renewing multipotent neural progenitors in the developing forebrain. MERK phosphorylates zinc finger protein 622 (ZNF622) and may contribute to its redirection to the nucleus. MERK may be involved in the inhibition of spliceosome assembly during mitosis.

GenScript Rabbit Anti-MELK Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human MELK. (Swiss Prot: Q14680).
Synonyms Rabbit Anti-MELK pAb;
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Citations
Hu Y, et al. Tumor-Specific Chromosome Mis-Segregation Controls Cancer Plasticity by Maintaining Tumor Heterogeneity. PLoS One. (2013-11)