MELK Antibody, pAb, Rabbit
*This product has been discontinued!*
MELK (Maternal Embryonic Leucine zipper Kinase, Protein kinase PK38) is one member of the Snf1/AMPK related kinase family of serine/threonine kinases. MELK kinase contains an N-terminal serine/threonine kinase domain that includes all 12 typical catalytic subdomains, and a KA1 (kinase-associated) domain. It is implicated in stem cell renewal, cell cycle progression, and pre-m-RNA splicing. The kinase is also a marker for self-renewing multipotent neural progenitors in the developing forebrain. MERK phosphorylates zinc finger protein 622 (ZNF622) and may contribute to its redirection to the nucleus. MERK may be involved in the inhibition of spliceosome assembly during mitosis.GenScript Rabbit Anti-MELK Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human MELK. (Swiss Prot: Q14680).
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