Nurr1 Antibody, pAb, Rabbit

*This product has been discontinued!*

GenScript Nurr1 Antibody, pAb, Rabbit detects human Nurr1 protein. Predicted to react with rat and mouse Nurr1 protein according to sequence homology.

Cat. No.	A01425
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Overview Applications Properties Background Bottom Notes

Overview

Specificity	GenScript Nurr1 Antibody, pAb, Rabbit detects human Nurr1 protein. Predicted to react with rat and mouse Nurr1 protein according to sequence homology.
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide within residues 310~360 of human Nurr1 protein (Swiss Prot: P43354)
Species Reactivity	Human. Reactivity to other species is not tested yet.
Conjugate	Unconjugated

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Applications

Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.

Application	Recommended Usage
Western Blot	1-2 µg/ml
Other applications	User-optimized

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Properties

Form	Lyophilized
Storage Buffer	lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/mL.
Storage Instructions	The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
Purification	Affinity chromatography
Isotype	Rabbit IgG
Clonality	Polyclonal
Clone ID	Not applicable

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Background

Target Background

Nurr1 is a transcription factor and belongs to the Nur77 family of orphan receptors. This family of transcription factors plays key roles in the development and the effector functions of T lymphocytes. Nurr1 promote signaling via its heterodimerization partner, the retinoid X receptor (RXR). Nurr1 protein is expressed in the embryonic ventral midbrain and it is critical for the development of dopamine neurons. In addition, Nurr1 has been implicated in the maintenance of adult dopaminergic neurons. GenScript Nurr1 Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 310~360 of human Nurr1 protein (Swiss Prot: P43354).

Synonyms

RNR1 Antibody, pAb, Rabbit;

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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.