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Calreticulin Antibody, pAb, Rabbit

Cat. No.	Name	Size	Price
A01443-200	Calreticulin Antibody, pAb, Rabbit	200 μg(5x40μg)	$225
A01443-40	Calreticulin Antibody, pAb, Rabbit	40 μg	$50

Full Name

Calreticulin Antibody, pAb, Rabbit

Abbreviated name-1

Rabbit Anti-CALR antibody;

Documents
Document-MSDS: 10123_20090710021700.PDF (PDF)
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Reference

Description

Calreticulin is a multifunctional protein that serves as a major Ca²⁺-binding protein in the lumen of the endoplasmic reticulum. It binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of nuclear receptors. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin also serves as a recognition and clearance ligand by activating the internalization receptor LRP1 on the responding phagocyte cell surface.
GenScript Rabbit Anti-Calreticulin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Calreticulin (Swiss Prot: P27797).

Ig Subclass

Rabbit IgG

Storage

The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Specificity

GenScript Rabbit Anti-Calreticulin Polyclonal Antibody detects endogenous levels of human Calreticulin. It is predicted to react with mouse and rat Calreticulin according to sequence homology.
Positive Control: Hela and HepG2

Concentration

0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide

Immunogen

KLH-coupled synthetic peptide from C-terminal of human Calreticulin (Swiss Prot: P27797).

Purification Method

Immunoaffinity chromatography.

Reconstitution

Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.

Applications

Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Western blot: 0.5-1 µg/ml
Other Applications: user-optimized

Conjugation

Unconjugated

Species Reactivity

Human. This product has not been tested for other species yet.

Host Species

Rabbit

Antigen Species

Human

Technical Manual

TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)


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