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Lamin A+C Antibody, pAb, Rabbit


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Cat. No.
Product Name
Size
Price
Quantity
A01455-40 Lamin A+C Antibody, pAb, Rabbit
40 μg
$99.00
A01455-100 Lamin A+C Antibody, pAb, Rabbit
100 μg
$199.00



Abbreviated name-1 Lamin A/C antibody;
Description Lamins are structural protein components of the nuclear lamina which contains 3 members: Lamin A, B and C in mammalian cells. Lamin A and lamin C are generated by alternative splicing from the same gene and share complete identity for the first 566 amino acids. Lamin A interacts with transcription factor SREBP1 via its C-terminal domain. The lamin A/C deficiency is probably associated with both defective nuclear mechanics and impaired transcriptional activation. The lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation.

GenScript Rabbit Anti-Lamin A+C Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 400-450 of human Lamin A (Swiss Prot: P02545).
Host Species Rabbit
Conjugation Unconjugated
Purification Method Immunoaffinity chromatography

Formulation 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Ig Subclass Rabbit IgG
Specificity GenScript Rabbit Anti-Lamin A+C Polyclonal Antibody detects endogenous levels of human and mouse Lamin A and Lamin C. It is predicted to react with rat Lamin A and Lamin C according to sequence homology.
Positive Control: Hela, A431, Lovo and NIH/3T3
Storage GenScript Rabbit Anti-Lamin A+C Polyclonal Antibody should be stored lyophilized until use. It remains stable in lyophilized form for at least two years if stored at -20°C or below. The reconstituted antibody can be stored for two to three weeks at 2-8°C or for up to 12 months at -20°C or below. Avoid repeated freeze and thaw cycles.


Lamin A+C Antibody, PAb, Rabbit

Lamin A+C Antibody, PAb, Rabbit

Lamin A+C Antibody, PAb, Rabbit

Lamin A+C Antibody, PAb, Rabbit

Lamin A+C Antibody, PAb, Rabbit
Lamin A+C Antibody, PAb, Rabbit

Western blot analysis of cell lysates using 1 µg/ml Rabbit Anti-Lamin A+C Polyclonal Antibody (GenScript, A01455)
The signal was developed with IRDyeTM 800 Conjugated Goat Anti-Rabbit IgG.
Predicted Size: Lamin A 71 KD Lamin C 65 KD
Observed Size: Lamin A 71 KD Lamin C 65 KD

Lamin A+C Antibody, PAb, Rabbit

Lamin A+C Antibody, PAb, Rabbit
Lamin A+C Antibody, PAb, Rabbit

Flow cytometric analysis of HepG2 cells using Lamin A+C Antibody, pAb, Rabbit (GenScript, A01455; shaded histogram)
or with an isotype control antibody (GenScript, A01008; open histogram), followed by R-PE conjugated anti-rabbit IgG.

Lamin A+C Antibody, PAb, Rabbit
Lamin A+C Antibody, PAb, Rabbit

Flow cytometric analysis of HepG2 cells using Lamin A+C Antibody, pAb, Rabbit (GenScript, A01455; shaded histogram)
or with an isotype control antibody (GenScript, A01008; open histogram), followed by R-PE conjugated anti-rabbit IgG.

Lamin A+C Antibody, PAb, Rabbit




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