Cat. No.
Name
Size   
Price
Selected
A01517-40
40 μg
$79 $47
A01517-100
100 μg
$198
IL-6 Antibody, mAb, Mouse
Full Name IL-6 Antibody, mAb, Mouse
Abbreviated name-1
BSF2 Antibody,mAb,Mouse; CDF Antibody,mAb,Mouse
Documents
IL-6 Antibody, mAb, MouseDocument-MSDS: 11617_20091228205621.PDF (PDF)
Figures
IL-6 Antibody, mAb, Mouse zoomIL-6 Antibody, mAb, Mouse
Description
Interleukin 6 (IL6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4 and TGF beta. IL6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass.
IL6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL6 appears to interact with IL2 in the proliferation of T lymphocytes. IL6 potentiates the proliferative effect of IL3 on multipotential hematopoietic progenitors.
Ig Subclass
Mouse IgG2b, κ
Storage
The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
Specificity
No cross reactivity with IL-1α, IL-1β, IL-4, IL-8, IL-18
Formulation
0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Immunogen
Human IL-6 recombinant protein
Clone ID
2F6H6
Purification Method
Protein A affinity column
Reconstitution
Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Fusion Partner
Spleen cells were fused with SP2/0-Ag14 mouse myeloma cells
Conjugation
Unconjugated
Host Species
Mouse
Antigen Species
Human
Technical Manual
ELISA Protocol (pdf)
Western Blot Protocol (pdf)
FACS Protocol (pdf)
IHC Protocol (pdf)
IP Protocol (pdf)
Document-COA
1
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