UBE3A antibody, pAb, Rabbit

*This product has been discontinued!*

UBE3A (Ubiquitin protein ligase E3A) is one member of the E3 ubiquitin-protein ligase family which plays a role in defining the substrate specificity of the ubiquitin-proteasome degradation system. UBE3A can interact directly with the growth and tumor-suppressive protein, p53 or indirectly as part of a human papillomavirus type 16 or 18 E6 protein complex. Mutations within the UBE3A gene are responsible for some cases of Angelman syndrome. Alternative splicing of UBE3A gene results in three transcript variants encoding three isoforms with different N-termini. GenScript UBE3A antibody is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human UBE3A (Swiss Prot: Q05086).

Cat. No.	A01603
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	UBE3A Antibody detects endogenous levels of human and mouse UBE3A. Positive Control: Hela, A549, HepG2, HT29 and mouse brain tissue
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide from N-terminal of human UBE3A (Swiss Prot: Q05086)
Species Reactivity	Human and Mouse

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

UBE3A (Ubiquitin protein ligase E3A) is one member of the E3 ubiquitin-protein ligase family which plays a role in defining the substrate specificity of the ubiquitin-proteasome degradation system. UBE3A can interact directly with the growth and tumor-suppressive protein, p53 or indirectly as part of a human papillomavirus type 16 or 18 E6 protein complex. Mutations within the UBE3A gene are responsible for some cases of Angelman syndrome. Alternative splicing of UBE3A gene results in three transcript variants encoding three isoforms with different N-termini.
GenScript UBE3A antibody is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human UBE3A (Swiss Prot: Q05086).

Synonyms

Ubiquitin protein ligase E3A Antibody;

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