Dysbindin antibody, pAb, Rabbit
|A01619-40||Dysbindin antibody, pAb, Rabbit||
|Abbreviated name-1||DTNBP1 antibody, pAb, Rabbit;|
|Description||Dysbindin, also known as dystrobrevin-binding protein 1 that contains acoiled-coil. Dysbindin upregulates expression of the pre-synaptic proteins SNAP25 and synapsin I, thereby increasing glutamate release and promoting neuronal viability through Akt signaling. It is a component of the biogenesis of lysosome-related organelles complex-1 (BLOC1), which regulates trafficking to lysosome-related organelles and includes the proteins pallidin, muted, and cappuccino. Dysbindin also binds to alpha- and beta-dystrobrevins，components of the dystrophin-associated protein complex.
GenScript Dysbindin Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 120–170 of human Dysbindin (Swiss Prot: Q96EV8).
|Immunogen||KLH-coupled synthetic peptide within residues 120–170 of human Dysbindin (Swiss Prot: Q96EV8)|
|Purification Method||Immunoaffinity chromatography|
|Formulation||0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide|
|Reconstitution||Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.|
|Ig Subclass||Rabbit IgG|
|Specificity||GenScript Dysbindin Antibody, pAb, Rabbit detects endogenous levels of human Dysbindin.
Positive Control: U251
|Storage||The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.|
|Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Western blot: 0.5-1 µg/ml
Immunohistochemistry: 5-10 µg/mlOther Applications: User optimized
|Technical Manual||ELISA Protocol(pdf)|
Western Blot Protocol(pdf)
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