Cat. No.
Name
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A01619-40
40 μg
$79 $47
Dysbindin antibody, pAb, Rabbitcustom antibody production
Dysbindin antibody, pAb, Rabbit
Full Name Dysbindin antibody, pAb, Rabbit
Abbreviated name-1
DTNBP1 antibody, pAb, Rabbit;
Documents
Dysbindin antibody, pAb, RabbitDocument-MSDS: 11944_20100226002347.PDF (PDF)
Figures
Dysbindin antibody, pAb, Rabbit zoomDysbindin antibody, pAb, Rabbit
Description
Dysbindin, also known as dystrobrevin-binding protein 1 that contains acoiled-coil. Dysbindin upregulates expression of the pre-synaptic proteins SNAP25 and synapsin I, thereby increasing glutamate release and promoting neuronal viability through Akt signaling. It is a component of the biogenesis of lysosome-related organelles complex-1 (BLOC1), which regulates trafficking to lysosome-related organelles and includes the proteins pallidin, muted, and cappuccino. Dysbindin also binds to alpha- and beta-dystrobrevins,components of the dystrophin-associated protein complex.
GenScript Dysbindin Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 120–170 of human Dysbindin (Swiss Prot: Q96EV8).
Ig Subclass
Rabbit IgG
Storage
The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.
Specificity
GenScript Dysbindin Antibody, pAb, Rabbit detects endogenous levels of human Dysbindin.
Positive Control: U251
Concentration
0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Immunogen
KLH-coupled synthetic peptide within residues 120–170 of human Dysbindin (Swiss Prot: Q96EV8)
Purification Method
Immunoaffinity chromatography
Reconstitution
Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Predicted Band Size
39 KD
Observed Band Size
55 KD
Applications
Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Western blot: 0.5-1 µg/ml
Other Applications: User optimized
Conjugation
Unconjugated
Species Reactivity
Human. This product has not been tested with other species yet.
Host Species
Rabbit
Antigen Species
Human
Technical Manual
ELISA Protocol (pdf)
Western Blot Protocol (pdf)
FACS Protocol (pdf)
IHC Protocol (pdf)
IP Protocol (pdf)
Document-COA
1
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