AMPKα1 Antibody, pAb, Rabbit

*This product has been discontinued!*

AMP-activated protein kinase (AMPK) plays an important role in the regulation of energy homeostasis. It is activated by an elevated AMP/ATP ratio caused by cellular and environmental stress, such as heat shock, hypoxia, and ischemia. AMPK is a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits, each of which is encoded by two or three distinct genes (α1, α2; β1, β2; γ1, γ2, γ3). Phosphorylation of AMPKα at Thr172 is the major regulatory site which is required for AMPK activation.GenScript AMPKα1 Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 500–550 of human AMPKα1 (Swiss Prot: Q13131).

Cat. No.	A01623
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	GenScript AMPKα1 Antibody, pAb, Rabbit detects endogenous levels of human AMPKα1 and does not cross-react with AMPKα2. It is predicted to react with mouse AMPKα1 according to sequence homology. Positive Control: HEK293 and MCF-7
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide within residues 500–550 of human AMPKα1 (Swiss Prot: Q13131)
Species Reactivity	Human

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

AMP-activated protein kinase (AMPK) plays an important role in the regulation of energy homeostasis. It is activated by an elevated AMP/ATP ratio caused by cellular and environmental stress, such as heat shock, hypoxia, and ischemia. AMPK is a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits, each of which is encoded by two or three distinct genes (α1, α2; β1, β2; γ1, γ2, γ3). Phosphorylation of AMPKα at Thr172 is the major regulatory site which is required for AMPK activation.
GenScript AMPKα1 Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 500–550 of human AMPKα1 (Swiss Prot: Q13131).

Synonyms

AMPK1 antibody, pAb, Rabbit ;

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