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RNA polymerase II CTD repeat Antibody (Phospho-Ser2), pAb, Rabbit

*This product has been discontinued!*
RNA polymerase II is an integral part of the transcription initiation complex. It possesses a unique C-terminal domain (CTD) consisting of repeats of the consensus heptapeptide sequence YSPTSPS. The CTD domain interacts with a large multisubunit complex that contains TATA-binding protein (TBP). Phosphorylation of RNA polymerase IIs largest C-terminal domain (CTD) is a key event during mRNA metabolism. GenScript RNA polymerase II CTD repeat Antibody (Phospho-Ser2), pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic phosphopeptide corresponding to the residues surrounding Ser2 of human RNA polymerase II CTD repeat YSPTSPS (Swiss Prot: P24928).
A01633
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Overview
Specificity GenScript RNA polymerase II CTD repeat Antibody (Phospho-Ser2), pAb, Rabbit detects endogenous level of RNA polymerase II CTD repeat YSPTSPS, only when phosphorylated at serine 2 of YSPTSPS. This antibody has no cross-reactivity with RNA polymerase II, when phosphorylated at serine of YSPTSPS. Predicted to react with mouse and rat species according to sequence homology.
Positive Control: MCF-7, HEK293
Host Species Rabbit
Immunogen KLH-coupled synthetic phosphopeptide corresponding to the residues surrounding Ser2 of human RNA polymerase II CTD repeat YSPTSPS (Swiss Prot: P24928)
Species Reactivity Human. Reactivity to other species is not tested yet.
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Properties
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification Affinity chromatography using phospho-peptide, and cross-adsorbed with the corresponding non-phosphopeptide
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Background
Target Background RNA polymerase II is an integral part of the transcription initiation complex. It possesses a unique C-terminal domain (CTD) consisting of repeats of the consensus heptapeptide sequence YSPTSPS. The CTD domain interacts with a large multisubunit complex that contains TATA-binding protein (TBP). Phosphorylation of RNA polymerase IIs largest C-terminal domain (CTD) is a key event during mRNA metabolism.
GenScript RNA polymerase II CTD repeat Antibody (Phospho-Ser2), pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic phosphopeptide corresponding to the residues surrounding Ser2 of human RNA polymerase II CTD repeat YSPTSPS (Swiss Prot: P24928).
Synonyms RNA polymerase II CTD repeat YSPTSPS (phospho-Ser2) antibody;
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