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CD8 Antibody, mAb, Mouse

Cat. No.	Name	Size	Price
A01697-100	CD8 Antibody, mAb, Mouse	100 μg	$120
A01697-500	CD8 Antibody, mAb, Mouse	500 μg	$360

Full Name

CD8 Antibody, mAb, Mouse

Abbreviated name-1

CD8 Antibody, mAb, Mouse;

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Description

CD8 T cell surface antigen is heterodimer of an alpha and a beta chain linked by two disulfide bonds. It belongs type I membrane protein. Selectively expressing of CD8 on a subset of T cells leads to CD8 T cell development. Through identifying cytotoxic/suppressor T-cells that interact with MHC class I bearing targets, CD8 is thought to play a role in the process of T-cell mediated killing. Veillette et al (1988) found the CD8 is associated with the internal membrane tyrosine-protein kinase p56lck.

Ig Subclass

IgG1

Storage

GenScript CD8 Antibody, mAb, Mouse should be stored lyophilized until use. It remains stable in lyophilized form for at least two years if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 4-8°C or for up to 12 months at -20°C or below. Avoid repeated freezing and thawing cycles.

Specificity

GenScript CD8 Antibody, mAb, Mouse recognizes human CD8 antigen, a 32kD transmembrane protein present in the cytotoxic/suppressor T-lymphocyte or on the cell membrance of sinus-lining cells in human spleen. Approximately 80% of T-cells in bone marrow and gut epithelium react with this antibody.

Concentration

1 mg/ml, lyophilized in 0.01 M phosphate buffered saline and 0.01 M Tris-Gly buffer, pH 7.4, containing 15 mM sodium azide

Purification Method

Protein G affinity purified immunoglobulin

Applications

FACS: 1-2 μg/ml
ELISA/Immunoblotting: 1-2 μg/ml
Immunocytochemistry (frozen tissue): 10 μg/ml

Conjugation

Unconjugated

Species Reactivity

Human. Reactivity to other species is not tested yet.

Host Species

Mouse

Note

Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage.

Technical Manual

TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)


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