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CD8 Antibody, mAb, Mouse

*This product has been discontinued!*
CD8 T cell surface antigen is heterodimer of an alpha and a beta chain linked by two disulfide bonds. It belongs type I membrane protein. Selectively expressing of CD8 on a subset of T cells leads to CD8 T cell development. Through identifying cytotoxic/suppressor T-cells that interact with MHC class I bearing targets, CD8 is thought to play a role in the process of T-cell mediated killing. Veillette et al (1988) found the CD8 is associated with the internal membrane tyrosine-protein kinase p56lck.
A01697
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Overview
Specificity GenScript CD8 Antibody, mAb, Mouse recognizes human CD8 antigen, a 32kD transmembrane protein present in the cytotoxic/suppressor T-lymphocyte or on the cell membrance of sinus-lining cells in human spleen. Approximately 80% of T-cells in bone marrow and gut epithelium react with this antibody.
Host Species Mouse
Species Reactivity Human. Reactivity to other species is not tested yet.
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Properties
Concentration 1 mg/ml, lyophilized in 0.01 M phosphate buffered saline and 0.01 M Tris-Gly buffer, pH 7.4, containing 15 mM sodium azide
Purification Protein G affinity purified immunoglobulin
Clone ID A01697.01
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Background
Target Background CD8 T cell surface antigen is heterodimer of an alpha and a beta chain linked by two disulfide bonds. It belongs type I membrane protein. Selectively expressing of CD8 on a subset of T cells leads to CD8 T cell development. Through identifying cytotoxic/suppressor T-cells that interact with MHC class I bearing targets, CD8 is thought to play a role in the process of T-cell mediated killing. Veillette et al (1988) found the CD8 is associated with the internal membrane tyrosine-protein kinase p56lck.
Synonyms CD8 Antibody, mAb, Mouse;
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