Catalog Products » CD45 Antibody, mAb, Mouse
Manual
Manual
COAs

CD45 Antibody, mAb, Mouse

*This product has been discontinued!*
CD45, also known as leukocyte-common antigen (LCA) is an integral membrane protein tyrosine phosphatase expressed on leukocyte cell surface. It suppresses JAK kinases and negatively regulates cytokine receptor signaling. CD45 is essential for activation of T and B cells by mediating cell-to-cell contacts and regulating protein-tyrosine kinases involved in signal transduction. CD45 is also involved in integrin-mediated adhesion and migration of immune cells. It can be used to identify undifferentiated hematopoietic tumors as an antigenic marker.
A01700
Ask us a question
Overview
Specificity GenScript CD45 Antibody, mAb, Mouse recognizes human CD45 Leucocyte Common Antigen (LCA), a 180-240 kD protein expressed on B-cells, T-cells, and monocytes. It can also be used to differentiate lymphomas from carcinomas.
Host Species Mouse
Species Reactivity Human. Reactivity to other species is not tested yet.
Back

Properties
Concentration 1 mg/ml, lyophilized in 0.01 M phosphate buffered saline and 0.01 M Tris-Gly buffer, pH 7.4, containing 15 mM sodium azide
Purification Protein G affinity purified immunoglobulin
Clone ID A01700.01
Back

Background
Target Background CD45, also known as leukocyte-common antigen (LCA) is an integral membrane protein tyrosine phosphatase expressed on leukocyte cell surface. It suppresses JAK kinases and negatively regulates cytokine receptor signaling. CD45 is essential for activation of T and B cells by mediating cell-to-cell contacts and regulating protein-tyrosine kinases involved in signal transduction. CD45 is also involved in integrin-mediated adhesion and migration of immune cells. It can be used to identify undifferentiated hematopoietic tumors as an antigenic marker.
Synonyms CD45 Antibody, mAb, Mouse;
Back