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Homo sapiens (human)


Browse by Letter Index, Genomic Locus

homocysteine degradation I L-cysteine degradation IV
choline biosynthesis I arginine degradation III (arginine decarboxylase/agmatinase pathway)
proline degradation II valine degradation II
sucrose degradation mammals superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine
superpathway of leucine, valine, and isoleucine biosynthesis superpathway of lysine, threonine and methionine biosynthesis I
hypusine biosynthesis alanine biosynthesis II
arginine biosynthesis IV aspartate biosynthesis
arginine degradation I (arginase pathway) glutamate biosynthesis II
citrulline biosynthesis protein citrullination
proline biosynthesis I tyrosine biosynthesis IV
4-hydroxyphenylpyruvate biosynthesis GDP-glucose biosynthesis
glycogen biosynthesis II (from UDP-D-Glucose) UDP-N-acetyl-D-galactosamine biosynthesis I
acyl carrier protein metabolism mevalonate pathway I
NAD biosynthesis II (from tryptophan) decaprenyl diphosphate biosynthesis
geranylgeranyldiphosphate biosynthesis heme biosynthesis from uroporphyrinogen-III I
heme biosynthesis II ubiquinone-10 biosynthesis (eukaryotic)
glutathione redox reactions II glutathione redox reactions I
tetrahydrobiopterin biosynthesis I tetrahydrobiopterin biosynthesis II
catecholamine biosynthesis gamma-linolenate biosynthesis II (animals)
oleate biosynthesis I (plants) oleate biosynthesis II (animals)
palmitate biosynthesis I (animals) stearate biosynthesis I (animals)
3-phosphoinositide biosynthesis D-myo-inositol-5-phosphate metabolism
superpathway of inositol phosphate compounds cardiolipin biosynthesis II
phosphatidylethanolamine biosynthesis III zymosterol biosynthesis
cholesterol biosynthesis II (via 24,25-dihydrolanosterol) cholesterol biosynthesis I
cholesterol biosynthesis III (via desmosterol) superpathway of cholesterol biosynthesis
creatine-phosphate biosynthesis epoxysqualene biosynthesis
spermine biosynthesis spermidine biosynthesis
superpathway of polyamine biosynthesis II putrescine biosynthesis III
D-myo-inositol (1,4,5)-trisphosphate biosynthesis superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
D-myo-inositol (1,4,5)-trisphosphate degradation D-myo-inositol (1,3,4)-trisphosphate biosynthesis
D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis
inositol pyrophosphates biosynthesis 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
ethanol degradation oxidative ethanol degradation II (MEOS)
oxidative ethanol degradation III oxidative ethanol degradation I
methylglyoxal degradation VI methylglyoxal degradation III
histamine degradation dopamine degradation
putrescine degradation III branched-chain alpha-keto acid dehydrogenase complex
2-ketoglutarate dehydrogenase complex alanine degradation III
aspartate degradation II glutamate degradation III (via 4-aminobutyrate)
glutamate degradation X glutamine degradation I
histidine degradation VI histidine degradation III
isoleucine degradation I leucine degradation I
lysine degradation II lysine degradation V
superpathway of lysine degradation phenylalanine degradation I (aerobic)
tryptophan degradation X (mammalian, via tryptamine) tryptophan degradation XI (mammalian, via kynurenine)
tyrosine degradation I valine degradation I
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA acetate conversion to acetyl-CoA
2-oxobutanoate degradation I heme degradation
3-phosphoinositide degradation anandamide degradation

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Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle)
Pentose phosphate pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism Galactose metabolism
Ascorbate and aldarate metabolism Fatty acid biosynthesis
Fatty acid elongation in mitochondria Fatty acid metabolism
Synthesis and degradation of ketone bodies Steroid biosynthesis
Primary bile acid biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis
Steroid hormone biosynthesis Oxidative phosphorylation
Purine metabolism Caffeine metabolism
Pyrimidine metabolism Glycine, serine and threonine metabolism
Valine, leucine and isoleucine degradation Valine, leucine and isoleucine biosynthesis
Lysine biosynthesis Lysine degradation
Arginine and proline metabolism Histidine metabolism
Tyrosine metabolism Phenylalanine metabolism
Tryptophan metabolism Phenylalanine, tyrosine and tryptophan biosynthesis
beta-Alanine metabolism Taurine and hypotaurine metabolism
Selenocompound metabolism Cyanoamino acid metabolism
D-Glutamine and D-glutamate metabolism D-Arginine and D-ornithine metabolism
Glutathione metabolism Starch and sucrose metabolism
N-Glycan biosynthesis Other glycan degradation
Mucin type O-Glycan biosynthesis Other types of O-glycan biosynthesis
Amino sugar and nucleotide sugar metabolism Glycosaminoglycan degradation
Glycosaminoglycan biosynthesis - chondroitin sulfate Glycosaminoglycan biosynthesis - keratan sulfate
Glycosaminoglycan biosynthesis - heparan sulfate Glycerolipid metabolism
Inositol phosphate metabolism Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Glycerophospholipid metabolism Ether lipid metabolism
Arachidonic acid metabolism Linoleic acid metabolism
alpha-Linolenic acid metabolism Sphingolipid metabolism
Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo series
Glycosphingolipid biosynthesis - ganglio series Pyruvate metabolism
Glyoxylate and dicarboxylate metabolism Propanoate metabolism
Butanoate metabolism One carbon pool by folate
Thiamine metabolism Riboflavin metabolism
Vitamin B6 metabolism Nicotinate and nicotinamide metabolism
Pantothenate and CoA biosynthesis Biotin metabolism
Lipoic acid metabolism Folate biosynthesis
Retinol metabolism Porphyrin and chlorophyll metabolism
Terpenoid backbone biosynthesis Nitrogen metabolism
Sulfur metabolism Aminoacyl-tRNA biosynthesis
Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450
Drug metabolism - other enzymes Biosynthesis of unsaturated fatty acids
ABC transporters Ribosome
RNA polymerase Basal transcription factors
DNA replication Proteasome
Protein export PPAR signaling pathway
Base excision repair Nucleotide excision repair
Mismatch repair Homologous recombination
Non-homologous end-joining MAPK signaling pathway
ErbB signaling pathway Calcium signaling pathway
Cytokine-cytokine receptor interaction Phosphatidylinositol signaling system

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CXCR4-mediated signaling events FOXA2 and FOXA3 transcription factor networks
Hedgehog signaling events mediated by Gli proteins Alpha-synuclein signaling
Presenilin action in Notch and Wnt signaling Signaling events regulated by Ret tyrosine kinase
Regulation of retinoblastoma protein Angiopoietin receptor Tie2-mediated signaling
Stabilization and expansion of the E-cadherin adherens junction N-cadherin signaling events
TRAIL signaling pathway Ras signaling in the CD4+ TCR pathway
IL12-mediated signaling events Rapid glucocorticoid signaling
VEGFR1 specific signals Aurora A signaling
Visual signal transduction: Cones Arf1 pathway
LPA receptor mediated events IL27-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Sphingosine 1-phosphate (S1P) pathway
IL6-mediated signaling events IL4-mediated signaling events
E2F transcription factor network FOXM1 transcription factor network
IL12 signaling mediated by STAT4 S1P1 pathway
IL2 signaling events mediated by PI3K Direct p53 effectors
Signaling events mediated by VEGFR1 and VEGFR2 Calcium signaling in the CD4+ TCR pathway
EphrinA-EPHA pathway p38 MAPK signaling pathway
IL1-mediated signaling events amb2 Integrin signaling
Atypical NF-kappaB pathway Proteogylcan syndecan-mediated signaling events
BMP receptor signaling LPA4-mediated signaling events
Signaling events mediated by the Hedgehog family EphrinB-EPHB pathway
Syndecan-3-mediated signaling events Role of Calcineurin-dependent NFAT signaling in lymphocytes
Arf6 trafficking events ErbB2/ErbB3 signaling events
HIF-2-alpha transcription factor network LKB1 signaling events
Endothelins BARD1 signaling events
Osteopontin-mediated events EPHA2 forward signaling
Wnt signaling network Regulation of nuclear SMAD2/3 signaling
Regulation of p38-alpha and p38-beta a4b1 and a4b7 Integrin signaling
E-cadherin signaling events Trk receptor signaling mediated by PI3K and PLC-gamma
ALK1 signaling events Signaling events mediated by PRL
EGF receptor (ErbB1) signaling pathway Paxillin-independent events mediated by a4b1 and a4b7
Signaling events mediated by HDAC Class III Caspase cascade in apoptosis
RXR and RAR heterodimerization with other nuclear receptor IL2-mediated signaling events
Neurotrophic factor-mediated Trk receptor signaling Circadian rhythm pathway
FOXA1 transcription factor network Reelin signaling pathway
Insulin-mediated glucose transport S1P5 pathway
ALK2 signaling events Lissencephaly gene (LIS1) in neuronal migration and development
ALK1 pathway Ephrin A reverse signaling
Regulation of Telomerase IL2 signaling events mediated by STAT5
FGF signaling pathway Regulation of CDC42 activity
ErbB4 signaling events IGF1 pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes CDC42 signaling events
HIV-1 Nef: Negative effector of Fas and TNF-alpha VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by HDAC Class I TCR signaling in naive CD4+ T cells
Integrins in angiogenesis IL23-mediated signaling events
mTOR signaling pathway E-cadherin signaling in keratinocytes
Aurora C signaling Alternative NF-kappaB pathway
E-cadherin signaling in the nascent adherens junction ATF-2 transcription factor network
PLK1 signaling events a6b1 and a6b4 Integrin signaling
Plasma membrane estrogen receptor signaling Glypican 1 network

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Apoptosis Extrinsic Pathway for Apoptosis
Death Receptor Signalling FasL/ CD95L signaling
TNF signaling TRAIL signaling
Caspase-8 is formed from procaspase-8 Activation of Pro-Caspase 8
Intrinsic Pathway for Apoptosis Activation, myristolyation of BID and translocation to mitochondria
Activation of BH3-only proteins Activation of BAD and translocation to mitochondria
Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria
Activation of BIM and translocation to mitochondria Activation of BMF and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX
Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria
Apoptotic factor-mediated response Cytochrome c-mediated apoptotic response
Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage
SMAC-mediated apoptotic response SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes Apoptotic execution phase
Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins Breakdown of the nuclear lamina
Apoptosis induced DNA fragmentation Activation of DNA fragmentation factor
Stimulation of the cell death response by PAK-2p34 Regulation of Apoptosis
Regulation of activated PAK-2p34 by proteasome mediated degradation Regulation of PAK-2p34 activity by PS-GAP/RHG10
Axon guidance NCAM signaling for neurite out-growth
RAF activation MAP kinase cascade
MEK activation RAF phosphorylates MEK
ERK activation ERK1 activation
ERK2 activation NCAM1 interactions
Biological oxidations Phase 1 - Functionalization of compounds
Cytochrome P450 - arranged by substrate type Endogenous sterols
Sterols are 12-hydroxylated by CYP8B1 Xenobiotics
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP2E1 reactions
Fatty acids Eicosanoids
Vitamins Miscellaneous substrates
FMO oxidizes nucleophiles COX reactions
Amine Oxidase reactions Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs Ethanol oxidation
Phase II conjugation Glucuronidation
Formation of the active cofactor, UDP-glucuronate Cytosolic sulfonation of small molecules
Acetylation Methylation
Glutathione conjugation Glutathione synthesis
Amino Acid conjugation Conjugation of carboxylic acids
Conjugation of benzoate with glycine Conjugation of phenylacetate with glutamine
Conjugation of salicylate with glycine Botulinum neurotoxicity
Translocation of BoNT Light chain Proteolytic cleavage of SNARE complex proteins
BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin BoNT Light Chain Types A, C1, E cleave SNAP-25
Cell Cycle Checkpoints G1/S DNA Damage Checkpoints
p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response
Stabilization of p53 Transcriptional activation of p53 responsive genes
Transcriptional activation of cell cycle inhibitor p21 p53-Independent G1/S DNA damage checkpoint
p53-Independent DNA Damage Response Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
G2/M Checkpoints G2/M DNA damage checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex G2/M DNA replication checkpoint
Activation of ATR in response to replication stress Mitotic Spindle Checkpoint

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One Carbon Metabolism Mitochondrial Gene Expression
Urea cycle and metabolism of amino groups Myometrial Relaxation and Contraction Pathways
IL-4 signaling Pathway Osteopontin Signaling
ACE Inhibitor Pathway Vitamin D synthesis
GPCRs, Other Inflammatory Response Pathway
NLR proteins Synthesis and Degradation of Ketone Bodies
Osteoclast Signaling IL-5 Signaling Pathway
DNA Replication Angiogenesis
TGF-beta Receptor Signaling Pathway TFs Regulate miRNAs related to cardiac hypertrophy
Hypothetical Network for Drug Addiction Keap1-Nrf2 Pathway
Fluoropyrimidine Activity MAPK signaling pathway
Senescence and Autophagy GPCRs, Class B Secretin-like
EGFR1 Signaling Pathway Alanine and aspartate metabolism
MicroRNAs in cardiomyocyte hypertrophy Vitamin A and carotenoid metabolism
Proteasome Degradation TCA Cycle
DNA damage response Wnt Signaling Pathway
EBV LMP1 signaling Biogenic Amine Synthesis
Cytokines and Inflammatory Response Focal Adhesion
Nicotine Activity on Chromaffin Cells Apoptosis
Ganglio Sphingolipid Metabolism Wnt Signaling Pathway NetPath
G13 Signaling Pathway Ovarian Infertility Genes
Heart Development Translation Factors
Tamoxifen metabolism G1 to S cell cycle control
Androgen Receptor Signaling Pathway Alpha6-Beta4 Integrin Signaling Pathway
Cholesterol Biosynthesis TGF Beta Signaling Pathway
Cell cycle Endochondral Ossification
Diurnally regulated genes with circadian orthologs Glycolysis and Gluconeogenesis
Polyol pathway Integrin-mediated cell adhesion
Mitochondrial LC-Fatty Acid Beta-Oxidation Heme Biosynthesis
Signal Transduction of S1P Receptor Acetylcholine Synthesis
Glucuronidation Complement Activation, Classical Pathway
Glutathione metabolism Selenium Pathway
Kit Receptor Signaling Pathway DNA damage response (only ATM dependent)
Hypertrophy Model Pentose Phosphate Pathway
Arylamine metabolism Codeine and morphine metabolism
Adipogenesis Folate Metabolism
MAPK Cascade Hedgehog Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor metapathway biotransformation
Arachidonate Epoxygenase / Epoxide Hydrolase GPCRs, Class C Metabotropic glutamate, pheromone
Blood Clotting Cascade amino acid conjugation of benzoic acid
Osteoblast Signaling mRNA processing
ErbB signaling pathway Insulin Signaling
Selenium Metabolism and Selenoproteins Wnt Signaling Pathway and Pluripotency
Nuclear Receptors G Protein Signaling Pathways
Tryptophan metabolism Monoamine Transport
Statin Pathway Cytoplasmic Ribosomal Proteins
Toll-like receptor signaling pathway Glycogen Metabolism
IL-7 Signaling Pathway Nicotine Activity on Dopaminergic Neurons
Triacylglyceride Synthesis Electron Transport Chain
Monoamine GPCRs T Cell Receptor Signaling Pathway

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