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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


TP53 tumor protein p53 [Equus caballus (horse)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001202405 Equus caballus tumor protein p53 (TP53), mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

Related Services

Gene Symbol TP53
Entrez Gene ID 100062044
Full Name tumor protein p53
Synonyms
General protein information
Preferred Names
cellular tumor antigen p53
Names
cellular tumor antigen p53
tumor suppressor p53
Gene Type protein-coding
Organism Equus caballus (horse)
Genome

11

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_001202405, 320202966 NP_001189334, 320202967 cellular tumor antigen p53 ORF Sequence $400.00
KEGG
ecb04010MAPK signaling pathway
ecb04115p53 signaling pathway
ecb04110Cell cycle
ecb04310Wnt signaling pathway
ecb04210Apoptosis
ecb05016Huntington's disease
ecb05216Thyroid cancer
ecb05215Prostate cancer
ecb05014Amyotrophic lateral sclerosis (ALS)
ecb05210Colorectal cancer
ecb05200Pathways in cancer
ecb05223Non-small cell lung cancer
ecb05217Basal cell carcinoma
ecb05213Endometrial cancer
ecb05212Pancreatic cancer
ecb05219Bladder cancer
ecb05218Melanoma
ecb05214Glioma
ecb05220Chronic myeloid leukemia
ecb05222Small cell lung cancer
ecb04722Neurotrophin signaling pathway
ecb05160Hepatitis C
ecb05166HTLV-I infection
ecb05162Measles
ecb05168Herpes simplex infection
ecb04151PI3K-Akt signaling pathway
ecb05161Hepatitis B
ecb05202Transcriptional misregulation in cancer
ecb05205Proteoglycans in cancer
ecb05169Epstein-Barr virus infection
ecb05203Viral carcinogenesis
ecb05206MicroRNAs in cancer
ecb04919Thyroid hormone signaling pathway
GeneCards TP53
UniProt E9NME8

What is the normal function of the TP53 gene?

The TP53 gene provides instructions for making a protein called tumor protein p53. This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way.

Tumor protein p53 is located in the nucleus of cells throughout the body, where it binds directly to DNA. When the DNA in a cell becomes damaged by agents such as toxic chemicals, radiation, or ultraviolet (UV) rays from sunlight, this protein plays a critical role in determining whether the DNA will be repaired or the damaged cell will self-destruct (undergo apoptosis). If the DNA can be repaired, tumor protein p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. This process prevents cells with mutated or damaged DNA from dividing, which helps prevent the development of tumors.

Because tumor protein p53 is essential for regulating cell division and preventing tumor formation, it has been nicknamed the "guardian of the genome."

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