Sequence in raw or FASTA format:
TP53 tumor protein p53 [Equus caballus (horse)]
|Entrez Gene ID||100062044|
|Full Name||tumor protein p53|
|General protein information||
|Organism||Equus caballus (horse)|
|ecb04010||MAPK signaling pathway|
|ecb04115||p53 signaling pathway|
|ecb04310||Wnt signaling pathway|
|ecb05014||Amyotrophic lateral sclerosis (ALS)|
|ecb05200||Pathways in cancer|
|ecb05223||Non-small cell lung cancer|
|ecb05217||Basal cell carcinoma|
|ecb05220||Chronic myeloid leukemia|
|ecb05222||Small cell lung cancer|
|ecb04722||Neurotrophin signaling pathway|
|ecb05168||Herpes simplex infection|
|ecb04151||PI3K-Akt signaling pathway|
|ecb05202||Transcriptional misregulation in cancer|
|ecb05205||Proteoglycans in cancer|
|ecb05169||Epstein-Barr virus infection|
|ecb05206||MicroRNAs in cancer|
|ecb04919||Thyroid hormone signaling pathway|
What is the normal function of the TP53 gene?
The TP53 gene provides instructions for making a protein called tumor protein p53. This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way.
Tumor protein p53 is located in the nucleus of cells throughout the body, where it binds directly to DNA. When the DNA in a cell becomes damaged by agents such as toxic chemicals, radiation, or ultraviolet (UV) rays from sunlight, this protein plays a critical role in determining whether the DNA will be repaired or the damaged cell will self-destruct (undergo apoptosis). If the DNA can be repaired, tumor protein p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. This process prevents cells with mutated or damaged DNA from dividing, which helps prevent the development of tumors.
Because tumor protein p53 is essential for regulating cell division and preventing tumor formation, it has been nicknamed the "guardian of the genome."
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