Sequence in raw or FASTA format:
KLLN killin, p53-regulated DNA replication inhibitor [Homo sapiens (human)]
|Entrez Gene ID||100144748|
|Full Name||killin, p53-regulated DNA replication inhibitor|
|General protein information|
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012].|
|Homo sapiens (human)||KLLN||NP_001119521.1|
|Pan troglodytes (chimpanzee)||KLLN||XP_003312729.1|
|Macaca mulatta (Rhesus monkey)||LOC100426503||XP_002805787.1|
What is the normal function of the KLLN gene?
The KLLN gene provides instructions for making a protein called killin. The activity of the KLLN gene is controlled by a protein called p53 (which is produced from the TP53 gene). Little is known about the function of killin, although it is thought to trigger cells to self-destruct (undergo apoptosis) when they are damaged or no longer needed. In this way, killin helps to prevent abnormal cells from growing and dividing unchecked to form tumors. Based on this role, killin is thought to be a tumor suppressor.
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