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KLLN killin, p53-regulated DNA replication inhibitor [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001126049 Homo sapiens killin, p53-regulated DNA replication inhibitor (KLLN), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol KLLN
Entrez Gene ID 100144748
Full Name killin, p53-regulated DNA replication inhibitor
Synonyms CWS4, KILLIN
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q23

Summary The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012].
Disorder

MIM: 612105

mRNA Protein Product Sequence Price Select
NM_001126049, 186700630 NP_001119521, 186700631 killin ORF Sequence $159.00
Homo sapiens (human)KLLNNP_001119521.1
Pan troglodytes (chimpanzee)KLLNXP_003312729.1
Macaca mulatta (Rhesus monkey)LOC100426503XP_002805787.1
Process
IDNameEvidence
GO:0006915apoptotic processIEA
GO:0007049cell cycleIEA
Component
IDNameEvidence
GO:0005634nucleusIEA
Function
IDNameEvidence
GO:0003677DNA bindingIEA
GeneCards KLLN
UniProt B2CW77
Vega OTTHUMG00000186455
MIM 612105
Ensembl ENSG00000227268
HGNC 37212

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the KLLN gene?

The KLLN gene provides instructions for making a protein called killin. The activity of the KLLN gene is controlled by a protein called p53 (which is produced from the TP53 gene). Little is known about the function of killin, although it is thought to trigger cells to self-destruct (undergo apoptosis) when they are damaged or no longer needed. In this way, killin helps to prevent abnormal cells from growing and dividing unchecked to form tumors. Based on this role, killin is thought to be a tumor suppressor.

Interactant

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