Sequence in raw or FASTA format:
EBI3 Epstein-Barr virus induced 3 [
Homo sapiens (human)]
Gene Symbol EBI3
Entrez Gene ID
Full Name Epstein-Barr virus induced 3
Synonyms IL-27B, IL27B
General protein information
interleukin-27 subunit beta
interleukin-27 subunit beta
IL-27 subunit beta
EBV-induced gene 3 protein
Epstein-Barr virus induced gene 3
epstein-Barr virus-induced gene 3 protein
Gene Type protein-coding
Homo sapiens (human)
Chromosome:19 Map Location:19p13.3
Summary This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008].
Pathway Interaction Database
ID Name Evidence
GO:0006959 humoral immune response TAS
GO:0019221 cytokine-mediated signaling pathway IEA
GO:0019221 cytokine-mediated signaling pathway IPI
GO:0042088 T-helper 1 type immune response TAS
GO:0045078 positive regulation of interferon-gamma biosynthetic process TAS
GO:0046641 positive regulation of alpha-beta T cell proliferation TAS
Related articles in PubMed IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells. Long J, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23154182. Association between polymorphisms in FOXP3 and EBI3 genes and the risk for development of allergic rhinitis in Chinese subjects. Zhang Y, et al. Hum Immunol, 2012 Sep. PMID 22836044. Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. Liu L, et al. J Biol Chem, 2012 Apr 6. PMID 22343630. Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma. Gonin J, et al. PLoS One, 2011. PMID 21931777. Detectable expression of IL-35 in CD4+ T cells from peripheral blood of chronic hepatitis B patients. Liu F, et al. Clin Immunol, 2011 Apr. PMID 21285006. See all (20) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
these results reveal a novel functional role for IL-35 in suppressing cancer activity, inhibiting cancer cell growth, and increasing the apoptosis sensitivity of human cancer cells through the regulation of genes related to the cell cycle and apoptosis.
Title: IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells.
The findings of this study support the potential role of regulatory T cells and genetic variations in the regions around FOXP3 and EBI3 genes in modifying the risk for AR development in Chinese patients.
Title: Association between polymorphisms in FOXP3 and EBI3 genes and the risk for development of allergic rhinitis in Chinese subjects.
This study demonstrated that interleukin-35 expression could be detected in the CD4(+) T cells from peripheral blood of chronic hepatitis B patients.
Title: Detectable expression of IL-35 in CD4+ T cells from peripheral blood of chronic hepatitis B patients.
IL-27 expression is one host immune factor produced in response to influenza A virus infection and that elevated IL-27 levels inhibit viral replication.
Title: Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling.
Data show that Epstein-Barr virus-induced gene 3 (EBI3) is differentially expressed among Burkitt lymphoma and diffuse large B-cell lymphoma.
Title: Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.
Our data support a possible role of Ebi3 in atherogenesis
Title: Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques.
findings indicate that the restricted Th1 responses in newborns owing to deficient IL-12 production may be compensated for, in part, by enhanced IL-27 secretion
Title: Enhanced expression of IL-27 mRNA in human newborns.
The genome-wide mRNA expression profile under the condition of short-term stimulation (4h) with IL-18 using the Affymetrix GeneChip((R)) Array System, was characterized.
Title: Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor.
results suggest that increased numbers of Epstein-Barr virus-infected cells in areas of active inflammatory bowel disease are secondary to influx or local proliferation of inflammatory cells & do not contribute significantly to local production of EBI3
Title: Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease.
a new heterodimeric cytokine that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide (IL-27)
Title: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.
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