EBI3 Epstein-Barr virus induced 3 [Homo sapiens (human)]
| Gene Symbol | EBI3 |
| Entrez Gene ID | 10148 |
| Full Name | Epstein-Barr virus induced 3 |
| Synonyms | IL-27B, IL27B |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19p13.3 |
| Summary | This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq]. |
| Disorder | MIM: 605816 |
| mRNA | NM_005755, 14577916 |
| Protein | NP_005746, 14577917 |
| Product | interleukin-27 subunit beta precursor |
| RefSeq Status | REVIEWED |
| il27pathway | IL27-mediated signaling events |
| Homo sapiens (human) | EBI3 | NP_005746.2 |
| Pan troglodytes (chimpanzee) | EBI3 | XP_001138182.1 |
| Canis lupus familiaris (dog) | EBI3 | XP_542161.2 |
| Bos taurus (cattle) | EBI3 | NP_001093835.1 |
| Mus musculus (house mouse) | Ebi3 | NP_056581.1 |
| Rattus norvegicus (Norway rat) | Ebi3 | XP_001057970.1 |
| Danio rerio (zebrafish) | ebi3 | NP_001106980.1 |
| ID | Name | Evidence |
| GO:0006959 | humoral immune response | TAS |
| GO:0019221 | cytokine-mediated signaling pathway | IPI |
| GO:0042088 | T-helper 1 type immune response | TAS |
| GO:0045078 | positive regulation of interferon-gamma biosynthetic process | TAS |
| GO:0046641 | positive regulation of alpha-beta T cell proliferation | TAS |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0005615 | extracellular space | IEA |
| GO:0005886 | plasma membrane | TAS |
Function
| ID | Name | Evidence |
| GO:0004896 | cytokine receptor activity | IPI |
| GO:0005125 | cytokine activity | IEA |
| GO:0045523 | interleukin-27 receptor binding | IEA |
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