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SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001160210 Homo sapiens solute carrier family 25 (aspartate/glutamate carrier), member 13 (SLC25A13), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_014251 Homo sapiens solute carrier family 25 (aspartate/glutamate carrier), member 13 (SLC25A13), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
XM_006715830 PREDICTED: Homo sapiens solute carrier family 25 (aspartate/glutamate carrier), member 13 (SLC25A13), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006715831 PREDICTED: Homo sapiens solute carrier family 25 (aspartate/glutamate carrier), member 13 (SLC25A13), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006715832 PREDICTED: Homo sapiens solute carrier family 25 (aspartate/glutamate carrier), member 13 (SLC25A13), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006715833 PREDICTED: Homo sapiens solute carrier family 25 (aspartate/glutamate carrier), member 13 (SLC25A13), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006715834 PREDICTED: Homo sapiens solute carrier family 25 (aspartate/glutamate carrier), member 13 (SLC25A13), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

Related Services

Gene Symbol SLC25A13
Entrez Gene ID 10165
Full Name solute carrier family 25 (aspartate/glutamate carrier), member 13
Synonyms ARALAR2, CITRIN, CTLN2
General protein information
Preferred Names
calcium-binding mitochondrial carrier protein Aralar2
Names
calcium-binding mitochondrial carrier protein Aralar2
mitochondrial aspartate glutamate carrier 2
solute carrier family 25, member 13 (citrin)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q21.3

Summary This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Disorder

MIM: 603859

Citrullinemia, adult-onset type II, 603471 (3); Citrullinemia,

mRNA Protein Product Sequence Price Select
NM_001160210, 237649018 NP_001153682, 237649019 calcium-binding mitochondrial carrier protein Aralar2 isoform 1 ORF Sequence $700.00
NM_014251, 171906609 NP_055066, 7657581 calcium-binding mitochondrial carrier protein Aralar2 isoform 2 ORF Sequence $490.00
XM_006715830, 578813861 XP_006715893, 578813862 calcium-binding mitochondrial carrier protein Aralar2 isoform X1 ORF Sequence $700.00
XM_006715831, 578813863 XP_006715894, 578813864 calcium-binding mitochondrial carrier protein Aralar2 isoform X2 ORF Sequence $700.00
XM_006715832, 578813865 XP_006715895, 578813866 calcium-binding mitochondrial carrier protein Aralar2 isoform X3 ORF Sequence $700.00
XM_006715833, 578813867 XP_006715896, 578813868 calcium-binding mitochondrial carrier protein Aralar2 isoform X4 ORF Sequence $550.00
XM_006715834, 578813869 XP_006715897, 578813870 calcium-binding mitochondrial carrier protein Aralar2 isoform X5 ORF Sequence $400.00
Reactome
REACT_17015Metabolism of proteins
REACT_474Metabolism of carbohydrates
REACT_1520Gluconeogenesis
REACT_723Glucose metabolism
REACT_111217Metabolism
REACT_116125Disease
REACT_118595Mitochondrial protein import
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)SLC25A13NP_055066.1
Pan troglodytes (chimpanzee)SLC25A13XP_527824.3
Macaca mulatta (Rhesus monkey)SLC25A13XP_001088340.2
Canis lupus familiaris (dog)SLC25A13XP_852644.2
Bos taurus (cattle)SLC25A13XP_002686709.3
Mus musculus (house mouse)Slc25a13NP_001171043.1
Gallus gallus (chicken)SLC25A13NP_001012967.1
Xenopus (Silurana) tropicalis (western clawed frog)slc25a13NP_001107969.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0006006glucose metabolic processTAS
GO:0006094gluconeogenesisTAS
GO:0006754ATP biosynthetic processIDA
GO:0006810transportNAS
GO:0015810aspartate transportIDA
GO:0015813L-glutamate transportIDA
GO:0043490malate-aspartate shuttleIDA
GO:0044281small molecule metabolic processTAS
GO:0045333cellular respirationIDA
GO:0051592response to calcium ionIDA
GO:0055085transmembrane transportIEA
Component
IDNameEvidence
GO:0005739mitochondrionIDA
GO:0005743mitochondrial inner membraneISS
GO:0005743mitochondrial inner membraneTAS
GO:0005887integral component of plasma membraneNAS
Function
IDNameEvidence
GO:0005215transporter activityNAS
GO:0005313L-glutamate transmembrane transporter activityIDA
GO:0005509calcium ion bindingIDA
GO:0015183L-aspartate transmembrane transporter activityIDA
GeneCards SLC25A13
UniProt Q9UJS0
Vega OTTHUMG00000023074
MIM 603859
Ensembl ENSG00000004864
HGNC 10983
HPRD 04837

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SLC25A13 gene?

The SLC25A13 gene provides instructions for making a protein called citrin. This protein is active chiefly in the liver, kidneys, and heart. Within the cells of these organs, citrin is involved in transporting molecules into and out of energy-producing structures called mitochondria. Specifically, citrin carries a protein building block (amino acid) called glutamate into mitochondria and transports the amino acid aspartate out of mitochondria as part of a process called the malate-aspartate shuttle.

An adequate supply of aspartate must be transported out of mitochondria to participate in a process called the urea cycle. The urea cycle is a sequence of chemical reactions that takes place in liver cells. These reactions process excess nitrogen that is generated as the body uses proteins. The excess nitrogen is used to make a compound called urea, which is excreted from the body in urine.

Citrin participates in several other important cellular functions as part of the malate-aspartate shuttle. This protein plays a role in producing and breaking down simple sugars and making proteins. It is also involved in the production of nucleotides, which are the building blocks of DNA and its chemical cousin, RNA.

Interactant

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