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MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17491 NM_001127325 Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17491 NM_006341 Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu32926 XM_005263423 PREDICTED: Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu17491C NM_001127325 Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu17491C NM_006341 Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu32926C XM_005263423 PREDICTED: Homo sapiens MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol MAD2L2
Entrez Gene ID 10459
Full Name MAD2 mitotic arrest deficient-like 2 (yeast)
Synonyms MAD2B, POLZ2, REV7
General protein information
Preferred Names
mitotic spindle assembly checkpoint protein MAD2B
Names
mitotic spindle assembly checkpoint protein MAD2B
hREV7
REV7 homolog
MAD2-like protein 2
mitotic arrest deficient homolog-like 2
mitotic arrest deficient 2-like protein 2
polymerase (DNA-directed), zeta 2, accessory subunit
MAD2 (mitotic arrest deficient, yeast, homolog)-like 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36

Summary The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604094

mRNA Protein Product Sequence Price Select
NM_001127325, 187960078 NP_001120797, 187960079 mitotic spindle assembly checkpoint protein MAD2B ORF Sequence $159.00
NM_006341, 187960072 NP_006332, 187960073 mitotic spindle assembly checkpoint protein MAD2B ORF Sequence $159.00
XM_005263423, 530360484 XP_005263480, 530360485 mitotic spindle assembly checkpoint protein MAD2B isoform X1 ORF Sequence $300.00
KEGG
hsa04110Cell cycle
hsa05131Shigellosis
hsa04914Progesterone-mediated oocyte maturation
hsa04114Oocyte meiosis
hsa05100Bacterial invasion of epithelial cells
hsa_M00293DNA polymerase zeta complex
WikiPathways
WP179Cell cycle
Reactome
REACT_2198Translesion synthesis by DNA polymerases bypassing lesion on DNA template
REACT_216DNA Repair
REACT_822Translesion synthesis by Pol zeta
REACT_2174DNA Damage Bypass
Homo sapiens (human)MAD2L2NP_001120797.1
Pan troglodytes (chimpanzee)MAD2L2XP_001138745.1
Macaca mulatta (Rhesus monkey)MAD2L2XP_001104002.1
Canis lupus familiaris (dog)MAD2L2XP_544568.4
Bos taurus (cattle)MAD2L2NP_001039411.1
Mus musculus (house mouse)Mad2l2NP_082261.2
Gallus gallus (chicken)MAD2L2NP_001020749.1
Danio rerio (zebrafish)si:dkey-23c22.2NP_001017595.1
Danio rerio (zebrafish)LOC557968XP_685100.1
Arabidopsis thaliana (thale cress)REV7NP_564002.1
Xenopus (Silurana) tropicalis (western clawed frog)mad2l2NP_001231770.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0001558regulation of cell growthIGI
GO:0006281DNA repairTAS
GO:0006302double-strand break repairIGI
GO:0006351transcription, DNA-templatedIEA
GO:0007015actin filament organizationIMP
GO:0007067mitotic nuclear divisionIEA
GO:0007094mitotic spindle assembly checkpointTAS
GO:0010719negative regulation of epithelial to mesenchymal transitionIMP
GO:0010944negative regulation of transcription by competitive promoter bindingIMP
GO:0033138positive regulation of peptidyl-serine phosphorylationIDA
GO:0042177negative regulation of protein catabolic processIDA
GO:0042772DNA damage response, signal transduction resulting in transcriptionIDA
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0045893positive regulation of transcription, DNA-templatedIMP
GO:0060564negative regulation of mitotic anaphase-promoting complex activityIDA
GO:0090090negative regulation of canonical Wnt signaling pathwayIMP
GO:2000048negative regulation of cell-cell adhesion mediated by cadherinIMP
GO:2000678negative regulation of transcription regulatory region DNA bindingIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005680anaphase-promoting complexIDA
GO:0005737cytoplasmIEA
GO:0005819spindleIDA
GO:0016035zeta DNA polymerase complexIDA
Function
IDNameEvidence
GO:0001102RNA polymerase II activating transcription factor bindingIPI
GO:0005515protein bindingIPI
GO:0008432JUN kinase bindingIDA
GeneCards MAD2L2
PDB 4GK5, 4GK0, 3ABD, 3VU7, 4EXT, 3ABE
UniProt Q9UI95
Vega OTTHUMG00000002231
MIM 604094
Ensembl ENSG00000116670
HGNC 6764
HPRD 07246

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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