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Blast Method:


DLL3 delta-like 3 (Drosophila) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_016941 Homo sapiens delta-like 3 (Drosophila) (DLL3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_203486 Homo sapiens delta-like 3 (Drosophila) (DLL3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol DLL3
Entrez Gene ID 10683
Full Name delta-like 3 (Drosophila)
Synonyms SCDO1
General protein information
Preferred Names
delta-like protein 3
delta-like protein 3
drosophila Delta homolog 3
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

MIM: 602768

Spondylocostal dysostosis, autosomal recessive, 1, 277300 (3)

mRNA Protein Product Sequence Price Select
NM_016941, 189163470 NP_058637, 8393264 delta-like protein 3 isoform 1 precursor ORF Sequence $700.00
NM_203486, 189163469 NP_982353, 45243561 delta-like protein 3 isoform 2 precursor ORF Sequence $700.00
hsa04330Notch signaling pathway
WP268Notch Signaling Pathway
WP2064Neural Crest Differentiation
Pathway Interaction Database
notch_pathwayNotch signaling pathway
Homo sapiens (human)DLL3NP_058637.1
Pan troglodytes (chimpanzee)DLL3XP_003316395.1
Macaca mulatta (Rhesus monkey)DLL3XP_001088937.2
Canis lupus familiaris (dog)DLL3XP_005616942.1
Bos taurus (cattle)DLL3NP_001179009.2
Mus musculus (house mouse)Dll3NP_031892.2
Rattus norvegicus (Norway rat)Dll3NP_446118.1
GO:0001501skeletal system developmentIMP
GO:0007219Notch signaling pathwayIEA
GO:0007386compartment pattern specificationIEA
GO:0048339paraxial mesoderm developmentIEA
GO:0050768negative regulation of neurogenesisIEA
GO:0016021integral component of membraneNAS
GO:0005112Notch bindingNAS
GeneCards DLL3
UniProt Q9NYJ7
Vega OTTHUMG00000183067
MIM 602768
Ensembl ENSG00000090932
HGNC 2909
HPRD 04140

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the DLL3 gene?

The DLL3 gene provides instructions for making a protein that helps control (regulate) the Notch pathway, an important pathway in embryonic development. The Notch pathway plays a critical role in the development of vertebrae. Specifically, the DLL3 protein and the Notch pathway are involved in separating future vertebrae from one another during early development, a complex process called somite segmentation. Although the exact mechanism of somite segmentation is unclear, it appears to require the activity of several proteins in the Notch pathway, including the NOTCH1 protein, to be turned on and off in a specific pattern (oscillate).

The DLL3 protein regulates the activity of the NOTCH1 protein. The DLL3 protein attaches (binds) to the inactive NOTCH1 protein and isolates (sequesters) it or marks it to be broken down so that it cannot be activated.


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