NEU3 sialidase 3 (membrane sialidase) [Homo sapiens (human)]
| Gene Symbol | NEU3 |
| Entrez Gene ID | 10825 |
| Full Name | sialidase 3 (membrane sialidase) |
| Synonyms | FLJ12388, SIAL3 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
11 11q13.5 |
| Summary | This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq]. |
| Disorder | MIM: 604617 |
| Homo sapiens (human) | NEU3 | NP_006647.3 |
| Canis lupus familiaris (dog) | NEU3 | XP_542313.2 |
| Bos taurus (cattle) | NEU3 | NP_776547.1 |
| Mus musculus (house mouse) | Neu3 | NP_057929.1 |
| Rattus norvegicus (Norway rat) | Neu3 | NP_446462.1 |
| Gallus gallus (chicken) | NEU3 | XP_428099.2 |
| Danio rerio (zebrafish) | neu3.2 | NP_001003644.2 |
| Danio rerio (zebrafish) | neu3.3 | NP_001071006.1 |
| Danio rerio (zebrafish) | LOC100332689 | XP_002666011.1 |
| Danio rerio (zebrafish) | neu3.5 | NP_001103203.1 |
| Danio rerio (zebrafish) | LOC100331972 | XP_002666000.1 |
| Danio rerio (zebrafish) | neu3.4 | NP_001103193.1 |
| Danio rerio (zebrafish) | LOC100332764 | XP_002666012.1 |
| Danio rerio (zebrafish) | neu3.1 | NP_001073133.1 |
| Danio rerio (zebrafish) | LOC100332630 | XP_002666010.1 |
| ID | Name | Evidence |
| GO:0005975 | carbohydrate metabolic process | IDA |
| GO:0006689 | ganglioside catabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | IDA |
| GO:0005887 | integral to plasma membrane | TAS |
Function
| ID | Name | Evidence |
| GO:0003824 | catalytic activity | TAS |
| GO:0004308 | exo-alpha-sialidase activity | IEA |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA |
| GO:0016997 | alpha-sialidase activity | IDA |
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