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NEU3 sialidase 3 (membrane sialidase) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu30315 NM_006656 Homo sapiens sialidase 3 (membrane sialidase) (NEU3), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu30315C NM_006656 Homo sapiens sialidase 3 (membrane sialidase) (NEU3), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol NEU3
Entrez Gene ID 10825
Full Name sialidase 3 (membrane sialidase)
Synonyms SIAL3
General protein information
Preferred Names
sialidase-3
Names
sialidase-3
neuraminidase 3
membrane sialidase
ganglioside sialidase
N-acetyl-alpha-neuraminidase 3
NP_006647.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13.5

Summary This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604617

mRNA Protein Product Sequence Price Select
NM_006656, 117190518 NP_006647, 117190519 sialidase-3 ORF Sequence $550.00
KEGG
hsa00600Sphingolipid metabolism
hsa00511Other glycan degradation
Reactome
REACT_19323Sphingolipid metabolism
REACT_17015Metabolism of proteins
REACT_22258Metabolism of lipids and lipoproteins
REACT_22161Post-translational protein modification
REACT_22426Asparagine N-linked glycosylation
REACT_22433Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
REACT_22387Synthesis of substrates in N-glycan biosythesis
REACT_111217Metabolism
REACT_116105Glycosphingolipid metabolism
REACT_200874Sialic acid metabolism
Homo sapiens (human)NEU3NP_006647.3
Pan troglodytes (chimpanzee)NEU3XP_003952031.1
Macaca mulatta (Rhesus monkey)LOC694310XP_002808128.1
Canis lupus familiaris (dog)NEU3XP_005633558.1
Bos taurus (cattle)NEU3NP_776547.2
Mus musculus (house mouse)Neu3NP_057929.1
Rattus norvegicus (Norway rat)Neu3NP_446462.1
Gallus gallus (chicken)NEU3XP_428099.4
Danio rerio (zebrafish)neu3.2NP_001003644.2
Danio rerio (zebrafish)neu3.3NP_001071006.1
Danio rerio (zebrafish)neu3.4NP_001103193.1
Danio rerio (zebrafish)neu3.5NP_001103203.1
Danio rerio (zebrafish)neu3.1NP_001073133.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100496715XP_002942460.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processIDA
GO:0006665sphingolipid metabolic processTAS
GO:0006687glycosphingolipid metabolic processTAS
GO:0006689ganglioside catabolic processIDA
GO:0009313oligosaccharide catabolic processIDA
GO:0044281small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
Function
IDNameEvidence
GO:0004308exo-alpha-sialidase activityIDA
GO:0016997alpha-sialidase activityIDA
GO:0052794exo-alpha-(2->3)-sialidase activityISS
GO:0052795exo-alpha-(2->6)-sialidase activityIEA
GO:0052796exo-alpha-(2->8)-sialidase activityISS
GeneCards NEU3
UniProt Q9UQ49
MIM 604617
HGNC 7760
HPRD 05215

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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