Sequence in raw or FASTA format:
SRCAP Snf2-related CREBBP activator protein [Homo sapiens (human)]
|Entrez Gene ID||10847|
|Full Name||Snf2-related CREBBP activator protein|
|Synonyms||DOMO1, EAF1, FLHS, SWR1|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012].|
|Homo sapiens (human)||SRCAP||NP_006653.2|
|Pan troglodytes (chimpanzee)||SRCAP||XP_003315112.1|
|Macaca mulatta (Rhesus monkey)||SRCAP||XP_002802498.1|
|Canis lupus familiaris (dog)||SRCAP||XP_005621350.1|
|Bos taurus (cattle)||SRCAP||XP_003587880.1|
|Mus musculus (house mouse)||Srcap||XP_006508489.1|
|Rattus norvegicus (Norway rat)||Srcap||XP_006230438.1|
|GO:0006357||regulation of transcription from RNA polymerase II promoter||TAS|
|GO:0003713||transcription coactivator activity||TAS|
|GO:0004402||histone acetyltransferase activity||TAS|
What is the normal function of the SRCAP gene?
The SRCAP gene provides instructions for making a protein called Snf2-related CREBBP activator protein, or SRCAP. SRCAP is one of several proteins that help activate a gene called CREBBP. The protein produced from the CREBBP gene, called CREB binding protein, plays a key role in regulating cell growth and division and is important for normal development.
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.