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MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu15846 NM_173844 Homo sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock TBD $99.00
OHu21698 NM_006785 Homo sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock TBD $99.00
OHu51080 XM_005266644 PREDICTED: Homo sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu15846C NM_173844 Homo sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 2, mRNA. Customized vector In-stock TBD $149.00
OHu21698C NM_006785 Homo sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 1, mRNA. Customized vector In-stock TBD $149.00
OHu51080C XM_005266644 PREDICTED: Homo sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant X1, mRNA. Customized vector On-demand TBD $269.00

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Gene Symbol MALT1
Entrez Gene ID 10892
Full Name mucosa associated lymphoid tissue lymphoma translocation gene 1
Synonyms IMD12, MLT, MLT1
General protein information
Preferred Names
mucosa-associated lymphoid tissue lymphoma translocation protein 1
Names
mucosa-associated lymphoid tissue lymphoma translocation protein 1
paracaspase
caspase-like protein
MALT associated translocation
MALT lymphoma-associated translocation
MALT-lymphoma associated translocation
NP_006776.1
NP_776216.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18q21

Summary This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604860

MALT lymphoma (3)

mRNA Protein Product Sequence Price Select
NM_006785, 523425721 NP_006776, 5803078 mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform a ORF Sequence $660.00
NM_173844, 523425722 NP_776216, 27886566 mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform b ORF Sequence $660.00
XM_005266644, 530414085 XP_005266701, 530414086 mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 ORF Sequence $550.00
KEGG
hsa04662B cell receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa05152Tuberculosis
hsa04064NF-kappa B signaling pathway
WikiPathways
WP69TCR Signaling Pathway
Pathway Interaction Database
tcr_pathwayTCR signaling in naive CD4+ T cells
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
cd8tcrpathwayTCR signaling in naive CD8+ T cells
bcr_5pathwayBCR signaling pathway
Reactome
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_12555Downstream TCR signaling
REACT_12526TCR signaling
REACT_75774Adaptive Immune System
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_118656Activation of NF-kappaB in B cells
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
Homo sapiens (human)MALT1NP_006776.1
Pan troglodytes (chimpanzee)MALT1XP_523938.2
Macaca mulatta (Rhesus monkey)MALT1XP_001086151.1
Canis lupus familiaris (dog)MALT1XP_005615420.1
Bos taurus (cattle)MALT1XP_002697882.2
Mus musculus (house mouse)Malt1NP_766421.1
Rattus norvegicus (Norway rat)Malt1XP_003751846.1
Gallus gallus (chicken)LOC426852XP_004949059.1
Danio rerio (zebrafish)malt1bXP_005165669.1
Caenorhabditis elegansF22D3.6NP_495424.2
Xenopus (Silurana) tropicalis (western clawed frog)malt1XP_004910455.1
Process
IDNameEvidence
GO:0001923B-1 B cell differentiationIEA
GO:0002237response to molecule of bacterial originIEA
GO:0002726positive regulation of T cell cytokine productionIMP
GO:0006508proteolysisIDA
GO:0006952defense responseNAS
GO:0007250activation of NF-kappaB-inducing kinase activityIMP
GO:0009620response to fungusIEA
GO:0016567protein ubiquitinationIDA
GO:0031398positive regulation of protein ubiquitinationNAS
GO:0032743positive regulation of interleukin-2 productionIMP
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042098T cell proliferationIEA
GO:0042981regulation of apoptotic processIDA
GO:0043066negative regulation of apoptotic processNAS
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIMP
GO:0045087innate immune responseTAS
GO:0050852T cell receptor signaling pathwayIDA
GO:0050852T cell receptor signaling pathwayTAS
GO:0050856regulation of T cell receptor signaling pathwayIEA
GO:0050870positive regulation of T cell activationIC
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP
GO:0051168nuclear exportIDA
GO:0051259protein oligomerizationIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005886plasma membraneTAS
GO:0032449CBM complexNAS
GO:0043234protein complexIDA
GO:0048471perinuclear region of cytoplasmIEA
Function
IDNameEvidence
GO:0002020protease bindingIEA
GO:0004197cysteine-type endopeptidase activityNAS
GO:0004842ubiquitin-protein transferase activityIDA
GO:0004871signal transducer activityIMP
GO:0005515protein bindingIPI
GO:0008233peptidase activityIDA
GO:0019209kinase activator activityIMP
GO:0043621protein self-associationIPI
GeneCards MALT1
UniProt Q9UDY8, A8K5S1
Vega OTTHUMG00000132761
MIM 604860
Ensembl ENSG00000172175
HGNC 6819
HPRD 06892

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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